Epidural spinal cord stimulation for managing blood pressure and low back pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of epidural spinal cord stimulation (SCS) on arterial blood pressure in patients suffering from chronic low back pain and hypertension. It aims to determine if SCS can reduce blood pressure and whether higher baseline blood pressure predicts greater pain relief following the procedure. Additionally, the study will explore the electrophysiological responses elicited by different SCS waveforms using advanced techniques like electroencephalography and magnetoencephalography. Patients will be monitored before and after the SCS implant to assess changes in blood pressure and pain levels.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or Female, age 18-89
2. Chronic pain for more than 3 months
3. Willing to visit a research lab
4. Willing to undergo a blood draw
5. Able to provide written informed consent

Exclusion Criteria

1. History of neurological disease (e.g., dementias, Parkinson's)
2. History of stroke
3. Current diagnosis of cancer
4. Subject is unwilling or unable to comply with the protocol

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Marshall Holland, MD — The University of Alabama at Birmingham
• Study coordinator: Chris Gonzalez, MS
• Email: clgonzalez@uabmc.edu
• Phone: (205) 975-3732

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using ketone supplements to manage salt intake effects in older adults

  This study is testing if ketone supplements can help older adults manage the harmful effects of a high-salt diet on their heart health and blood pressure.

  Recruiting Indiana University · Bloomington, Indiana · NCT06868719

• Validating the CART BP ring cuffless blood pressure monitor

  This study will test whether the CART BP ring gives blood pressure readings that match the standard cuff method in adults with suspected high or low blood pressure.

  Recruiting Sky Labs · Seoul · NCT06513975

• Focused ultrasound treatment for high blood pressure

  This study is testing a new ultrasound treatment that aims to lower blood pressure by targeting fat around the kidneys in people with high blood pressure.

  Recruiting at 4 sites Suzhou Municipal Hospital · Nanjing, Jiangsu and 3 other locations · NCT06283758

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• TelTex4BP: A mobile program to help adults with hypertension in Nepal

  A mobile text and phone-based program (TelTex4BP) helps adults with high blood pressure in Nepal take their medicines and adopt healthier habits to lower blood pressure.

  Recruiting at 2 sites Central Department of Public Health · Kathmandu, Bagmati and 1 other locations · NCT05979168

• Reducing blood pressure to prevent cognitive decline in older adults

  This study is testing if better blood pressure management can help older adults with high blood pressure avoid memory problems and dementia.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05106036

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.