Observational study on dry eye in patients with primary Sjögren's syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with primary Sjögren's syndrome (pSS) who experience severe dry eye symptoms. It aims to establish a clinical cohort to explore the relationship between the primary organs affected by pSS and various biomarkers in tear fluid and blood. By analyzing these associations, the study seeks to enhance understanding of the pathogenesis, diagnosis, classification, and treatment of dry eye disease related to pSS. The research will also investigate the severity of ocular involvement and symptom progression in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All enrolled DED participants met the criterion of TFOS DEWS II Definition and Classification Report and pSS-DED group also met 2016ACR/EULAR pSS diagnosis and classification consensus.

Exclusion Criteria:

* (1) patients were diagnosed as any rheumatic or systematic diseases that would probably affect tear function except for pSS and DED. (2) had a history of ocular trauma or surgery. (3) had a history of wearing contact lens. (4) had concomitant ocular lesions such as acute inflammation or infection, glaucoma or eyelid abnormalities. (5) cannot cooperate properly or finish related examinations.

Where it's running

• Peking University Third Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Yun Feng, PhD
• Email: superjune@sina.com
• Phone: 13911572425

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.