Understanding how dry eye disease progresses
Defining mechanisms driving dry eye disease progression
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10898842
This study is looking into how dry eye disease, especially when connected to autoimmune issues like Sjögren's syndrome and rheumatoid arthritis, affects the cells in your eyes, with the hope of finding new ways to help manage the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10898842 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the progression of aqueous-deficient dry eye disease, which is often linked to autoimmune conditions like Sjögren's syndrome and rheumatoid arthritis. The study focuses on the cellular diversity and differentiation of corneal cells, aiming to understand how dry eye affects these cells and leads to various pathological changes. By examining both human patients and mouse models, the research seeks to uncover the impact of chronic inflammation on the cornea and its function. This could provide insights into potential therapeutic targets for managing dry eye disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with aqueous-deficient dry eye disease, particularly those with underlying autoimmune conditions.
Not a fit: Patients with dry eye disease not linked to autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from dry eye disease, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding dry eye disease mechanisms, but this specific approach to cellular diversity and differentiation is relatively novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KNOX, SARAH MONICA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KNOX, SARAH MONICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.