Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Three-minute eyelid closure to improve corneal curvature readings

Official title: The Effect of Eyelid Closure on the Quality Index of Keratometric Measurements: a Non-controlled Interventional Study

Run by Vienna Institute for Research in Ocular Surgery · NCT07297849 · Data updated 2026-11-12

This tests whether gently closing the eyelid for three minutes before corneal measurements helps improve keratometry accuracy for adults with a 'warning' keratometry quality index who are planning cataract surgery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment29 (estimated)
SponsorVienna Institute for Research in Ocular Surgery
Academic / other
Locations1 site (Vienna, State of Vienna)
StatusRecruiting
StartedNovember 7, 2024
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedDecember 22, 2025
Trial IDNCT07297849 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age 18+) preparing for cataract surgery who have a keratometry quality index of "warning" and can voluntarily and fully close their eyelids are ideal candidates.

Probably not a fit

Patients with severe corneal scarring or other conditions that compromise corneal integrity, recent ocular surgery, inability to close the eyelid, or unstable ocular surface disease are unlikely to benefit from this eyelid-closure intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site interventional protocol enrolls adults with a keratometry quality index flagged as "warning" and compares keratometry measurements before and after a three-minute period of eyelid closure. The procedure is noninvasive: standard preoperative corneal curvature (keratometry) is recorded, the participant closes the eyelid for three minutes, and keratometry is repeated to detect changes in measurement quality. Patients with severe corneal disease, recent ocular surgery, pregnancy or inability to close the eyelid are excluded. The trial is conducted at the Vienna Institute for Research in Ocular Surgery and focuses on a simple, low-risk maneuver to stabilize the tear film and reduce measurement error.

Why it matters

Potential benefit: If successful, this simple maneuver could reduce preoperative keratometry error and help achieve more accurate refractive outcomes after cataract surgery.

How similar studies have gone: Prior research shows tear film stability and osmolarity affect keratometry precision and that treating dry eye can improve measurements, but brief eyelid closure as a corrective maneuver has been relatively little studied and is a novel, low-tech approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 or older
* Written informed consent
* Keratometry quality index "warning"

Exclusion Criteria:

* Severe corneal conditions that may compromise corneal integrity (such as corneal scarring, etc.)
* Pregnancy (pregnancy test will be taken in women of reproductive age), nursing women
* Ocular surgery in the study eye in the three months preceding the study
* Inability of visual fixation (e.g. in patients with nystagmus)
* Inability of eyelid closure (e.g. in patients with facial nerve paralysis)

Where it's running

  • Vienna Institute for Research in Ocular Surgery (VIROS), Department of Ophthalmology
    Vienna, State of Vienna, Austria
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.