Understanding how aging affects dry eye disease through specific proteins
Defining the interplay of interferon-gamma and cathepsin S in age-related dry eye
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10703450
This study is looking at how aging affects dry eye symptoms and how a protein called cathepsin S might play a role in causing inflammation in the eyes of older adults, with the goal of finding better treatments for dry eye disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10703450 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between aging and dry eye disease, focusing on the role of a protein called cathepsin S. As people age, they often experience chronic inflammation in the eyes, which can lead to dry eye symptoms. The study aims to uncover how increased levels of cathepsin S in the eyes of older adults may contribute to this inflammation and the resulting dry eye condition. By examining the mechanisms involved, the research hopes to provide insights that could lead to better treatments for dry eye disease in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing symptoms of dry eye disease.
Not a fit: Patients who are younger and do not have symptoms of dry eye disease are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dry eye disease, enhancing the quality of life for older adults.
How similar studies have performed: Previous research has shown that targeting inflammatory processes in age-related conditions can lead to significant improvements, suggesting potential success for this approach.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE PAIVA, CINTIA S. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: DE PAIVA, CINTIA S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.