Condition

Dry Eye Disease (DED) clinical trials and research

• 20Clinical trials
• 2New in 30 days
• 10Countries

Newest Dry Eye Disease (DED) clinical trials

All recruiting trials (20)

• Can cyclosporine 0.1% eye drops improve comfort for contact lens wearers with dry eye

  This study tests whether a water-free cyclosporine eye drop (VEVYE) can reduce dry eye symptoms and improve comfort for adults who wear soft contact lenses.

  Recruiting Ocular Aesthetics, LLC dba Ocular Clinical Trials · Houston, Texas · NCT07904728

• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

  Recruiting University of Sulaimani · Sulaymaniyah, As Sulaymaniyah Governorate · NCT07873697

• Brillouin hydration mapping to study cornea health

  Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07780890

• Is Systane PRO Preservative Free as good as Blink Triple Care Preservative Free for dry eye symptoms

  This study tests whether Systane PRO Preservative Free works as well as Blink Triple Care Preservative Free to improve dry eye symptoms in adults over 4 weeks.

  Recruiting Phase 4 Gordon Schanzlin New Vision · La Jolla, California · NCT07745062

• TRYPTYR eye drops for dry eye disease

  This study tests TRYPTYR eye drops to see if they improve dry eye symptoms in adults with Dry Eye Disease.

  Recruiting Phase 4 NYU Langone Health · New York, New York · NCT07732010

• OTC lubricating eye drops for dry eye disease: tolerability and vision outcomes

  This trial tests whether a preservative-free OTC eye drop mix can be tolerated and improve symptoms and visual comfort in adults with dry eye disease.

  Recruiting Phase 4 Andover Research Eye Institute · Andover, Massachusetts · NCT07676084

• Dose-finding study of HUC1-394 in people with dry eye disease

  A study to see if different dosing schedules of HUC1-394 are safe and effective for adults with moderate to severe dry eye disease.

  Recruiting Phase 2 Huons Co., Ltd. · Seoul · NCT07656688

• Perioperative Miebo for LASIK-Associated Dry Eye

  This study tests whether Miebo taken four times daily around the time of LASIK can reduce eye dryness in adults with dry eye disease.

  Recruiting at 3 sites Phase 4 Vance Thompson Vision · Bozeman, Montana and 3 other locations · NCT07650708

• GLP-1 receptor agonists and dry eye in adults with type 2 diabetes and obesity

  This study tests whether GLP-1 receptor agonists affect dry eye disease in adults with type 2 diabetes and obesity.

  Recruiting Attikon Hospital · Athens · NCT07605572

• Topical eye drop for dry eye disease in adults

  This phase 2 trial tests whether DFL24498 eye drops improve symptoms of dry eye disease compared with a non-medicated vehicle in adults 18 and older.

  Recruiting at 13 sites Phase 2 Dompé Farmaceutici S.p.A · Chandler, Arizona and 23 other locations · NCT07503886

• BriTer Eyez Moisture Vue On-Demand Moisture Chamber for Dry Eye

  This study tests whether wearing the BriTer Eyez Moisture Vue on a two-hour period helps people with mild to moderate dry eye feel and see improvements in tear film and related measures.

  Recruiting University of Rochester · Rochester, New York · NCT07430735

• Eye drops combining an added medicinal ingredient with hyaluronic acid 0.3% versus hyaluronic acid 0.3% alone for moderate-to-severe dry eye

  We will test whether eye drops that combine an additional medicinal ingredient with hyaluronic acid 0.3% help adults with moderate-to-severe dry eye as well as or better than hyaluronic acid 0.3% alone.

  Recruiting at 2 sites FB Vision S.p.A · Cagliari, CA and 1 other locations · NCT07412860

• Kelulut honey as an add-on treatment for juvenile open-angle glaucoma

  This trial will test whether taking 30 g of Kelulut (stingless bee) honey daily for three months helps lower inflammation, protect retinal nerve fibers, and improve dry eye in people aged 15–40 with juvenile open-angle glaucoma who are already on standard treatment.

  Recruiting at 4 sites Phase 4 Universiti Sains Malaysia · Kota Bharu, Kelantan and 3 other locations · NCT07396441

• Crosslinked hyaluronate gel to help dry eye during cataract surgery

  This tests whether putting a crosslinked hyaluronate canalicular gel to block the tear ducts before cataract surgery helps people with dry eye disease who are getting advanced intraocular lenses.

  Recruiting Vance Thompson Vision · Sioux Falls, South Dakota · NCT07155057

• Evaluation of a portable device for diagnosing dry eye disease

  This study is testing a new portable device to see if it can accurately diagnose dry eye disease compared to traditional eye exams.

  Recruiting The Eye Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06984549

• 12-week 0.1% ciclosporin A eye drops to reduce immune cells on the eye surface in dry eye

  This trial will try 0.1% ciclosporin A eye drops for people with dry eye to see if the drops reduce inflammatory immune cells on the eye surface compared with mineral oil drops.

  Recruiting The University of New South Wales · Sydney, New South Wales · NCT06898853

• Lifitegrast eye drops for treating dry eye disease

  This study is testing if Lifitegrast eye drops can help people with dry eye disease feel better and improve their eye health.

  Recruiting Phase 3 Lunan Better Pharmaceutical Co., LTD. · Beijing, Beijing Municipality · NCT06879782

• Investigating the role of corneal nerves in dry eye disease

  This study looks at how the nerves in the eye relate to dry eye symptoms to see if they can help explain why some people have worse dry eye than others.

  Recruiting University of Applied Sciences and Arts Northwestern Switzerland · Olten · NCT06841471

• 3% trehalose eye drops for corneal barrier protection

  This trial will test whether using 3% trehalose eye drops for one month improves corneal barrier function in adults with moderate-to-severe dry eye.

  Recruiting Phase 4 Southern California College of Optometry at Marshall B. Ketchum University · Fullerton, California · NCT06655441

• Tixel treatment for symptoms of dry eye disease

  This study is testing if Tixel treatment can help people with dry eye disease feel better compared to a fake treatment.

  Recruiting Aston University · Birmingham · NCT06615453

Related topics

Quick answers

How many Dry Eye Disease (DED) clinical trials are recruiting right now?

20, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (10 trials), China (2 trials), United Kingdom (1 trial), South Korea (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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