Understanding how dry eye disease progresses
Defining mechanisms driving dry eye disease progression
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11046163
This study is looking into how dry eye disease gets worse in people with autoimmune conditions like Sjögren's syndrome and rheumatoid arthritis, to help find better ways to manage the symptoms by understanding the changes happening in the eye.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11046163 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that lead to the progression of dry eye disease, particularly in patients with autoimmune conditions like Sjögren's syndrome and rheumatoid arthritis. By examining the cellular changes in the cornea and the surrounding tissues, the study aims to identify how inflammation and other factors contribute to the worsening of dry eye symptoms. The research utilizes both human patient data and mouse models to explore the cellular diversity and differentiation in the cornea, which could reveal new insights into disease management.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with aqueous-deficient dry eye, particularly those with underlying autoimmune diseases.
Not a fit: Patients with dry eye disease not associated with autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients suffering from dry eye disease.
How similar studies have performed: Previous research has shown promising results in understanding dry eye disease through similar cellular and inflammatory approaches, indicating potential for success in this study.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KNOX, SARAH MONICA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KNOX, SARAH MONICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.