Understanding tear film stability to create new treatments for dry eye disease
Redefining the factors that determine tear film stability to develop novel therapeutics for evaporative dry eye disease
This study is looking at how to make tears last longer for people with dry eye by exploring a special ingredient found in rabbit tears that could help improve tear stability, with the hope of creating a new treatment that brings better relief for those suffering from evaporative dry eye disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10983731 on NIH RePORTER |
What this research studies
This research investigates the factors that contribute to the stability of the tear film, particularly in patients suffering from evaporative dry eye disease (EDED). By studying the differences in tear film lipids between rabbits and humans, researchers aim to identify new therapeutic options that can enhance tear film stability. The project includes developing a topical treatment based on a specific nonpolar lipid found in rabbit tears, which has shown promise in improving tear film stability in animal models. The ultimate goal is to create effective treatments that provide longer-lasting relief for patients with EDED.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with evaporative dry eye disease who experience symptoms such as dryness, irritation, and visual disturbances.
Not a fit: Patients with other forms of dry eye disease that do not involve tear film instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve the quality of life for patients suffering from dry eye disease.
How similar studies have performed: Previous research has shown success in using lipid-based therapies for ocular conditions, indicating potential for this novel approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Hisey, Erin Alissa — University of California at Davis
- Study coordinator: Hisey, Erin Alissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.