Understanding evaporative dry eye disease and its causes
Defining a new model of evaporative dry eye disease
This study is looking at dry eye disease by using special mice that have a gene missing, which helps researchers learn more about what causes this common eye problem and how we might be able to treat it better in people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11039647 on NIH RePORTER |
What this research studies
This research investigates evaporative dry eye disease (EDED), a common condition characterized by an abnormal tear film that causes inflammation and irritation of the eye. The study utilizes a unique mouse model that lacks a specific gene responsible for lipid synthesis in the tear film, mimicking the condition seen in human patients. By examining these mice, researchers aim to uncover the underlying mechanisms of EDED and explore potential new treatments. The findings could lead to better understanding and management of this prevalent eye disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with evaporative dry eye disease or those experiencing symptoms related to dry eyes.
Not a fit: Patients with aqueous deficient dry eye disease or those without any symptoms of dry eye may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from evaporative dry eye disease.
How similar studies have performed: While there has been research on dry eye disease, this specific approach using a novel animal model is relatively new and untested.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Leonard, Brian C. — University of California at Davis
- Study coordinator: Leonard, Brian C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.