Using cord blood eye drops to heal corneal damage in lung cancer patients
Official title: Personalized Approach in the Treatment of Patients Affected by Severe Dry Eye Associated With Therapy With EGFR Inhibitors (EGRFR-I) With Growth Factors in Cord Blood Serum (CBS) Eye Drops
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06830551 · Data updated 2026-11-12
This study is testing if eye drops made from cord blood can help lung cancer patients with EGFR mutations heal their eye damage caused by treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna) |
| Status | Recruiting |
| Started | September 12, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | February 17, 2025 |
| Trial ID | NCT06830551 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old with advanced cancer and EGFR mutations requiring anti-EGFR treatment.
✕Probably not a fit
Patients unable to independently store or administer the eye drops will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of cord blood serum eye drops in promoting the healing of corneal epithelium in patients receiving EGFR inhibitor treatment for lung cancer. The intervention involves administering these eye drops over a one-month period to assess their impact on corneal damage caused by the medication. The study focuses on oncology patients with EGFR mutations who are experiencing severe keratopathy as a side effect of their treatment.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the quality of life for patients suffering from corneal damage due to cancer therapies.
How similar studies have gone: While the use of cord blood serum in ocular treatments is promising, this specific approach is novel and has not been extensively tested in similar studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age over 18 years * oncology and advanced cancer patients who have EGFr mutation and who require treatment with antiEGFr drugs * signing of informed consent Exclusion Criteria: * Patients who are unable to store/administer the CSCO independently, or with the help of care-givers.
Where it's running
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IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy Recruiting
Study contacts
- Principal investigator: Luigi Fontana, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Luigi Fontana, MD
- Email: luigi.fontana6@unibo.it
- Phone: +390512142837
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.