Preventing dry eye disease and age-related Meibomian gland dysfunction
Modifying the extracellular matrix to prevent dry eye disease and age-related Meibomian gland dysfunction (ARMGD)
['FUNDING_R01'] · UNIVERSITY OF HOUSTON · NIH-11160450
This study is looking at how changing the support structure around eye glands might help prevent dry eye and related issues as we age, and it aims to find new ways to help people who struggle with dry eyes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11160450 on ClinicalTrials.gov |
What this research studies
This research investigates how modifying the extracellular matrix can help prevent dry eye disease and age-related Meibomian gland dysfunction. It focuses on understanding the changes in Meibomian glands as people age and how these changes contribute to dry eye symptoms. The study uses animal models to explore the role of hyaluronan, a key component of the extracellular matrix, in maintaining healthy Meibomian gland function. By identifying the mechanisms behind these age-related changes, the research aims to develop new therapeutic strategies for patients suffering from dry eye disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing symptoms of dry eye disease, particularly those with age-related Meibomian gland dysfunction.
Not a fit: Patients with dry eye disease not related to Meibomian gland dysfunction or those with other underlying conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate the symptoms of dry eye disease and improve the quality of life for affected individuals.
How similar studies have performed: Previous research has shown promising results in modifying extracellular components to improve gland function, suggesting potential success for this approach.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COULSON-THOMAS, VIVIEN JANE — UNIVERSITY OF HOUSTON
- Study coordinator: COULSON-THOMAS, VIVIEN JANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.