Preventing dry eye disease and age-related Meibomian gland dysfunction
Official title: Modifying the extracellular matrix to prevent dry eye disease and age-related Meibomian gland dysfunction (ARMGD)
Funded at University of Houston · NIH-11160450 · Data updated 2026-11-12
This study is looking at how changing the support structure around eye glands might help prevent dry eye and related issues as we age, and it aims to find new ways to help people who struggle with dry eyes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $387,500 |
| NIH project number | 5R01EY033024-04 |
| Project ID | NIH-11160450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing symptoms of dry eye disease, particularly those with age-related Meibomian gland dysfunction.
✕Less likely to help
Patients with dry eye disease not related to Meibomian gland dysfunction or those with other underlying conditions may not benefit from this research.
What this research studies
This research investigates how modifying the extracellular matrix can help prevent dry eye disease and age-related Meibomian gland dysfunction. It focuses on understanding the changes in Meibomian glands as people age and how these changes contribute to dry eye symptoms. The study uses animal models to explore the role of hyaluronan, a key component of the extracellular matrix, in maintaining healthy Meibomian gland function. By identifying the mechanisms behind these age-related changes, the research aims to develop new therapeutic strategies for patients suffering from dry eye disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate the symptoms of dry eye disease and improve the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in modifying extracellular components to improve gland function, suggesting potential success for this approach.
Where this research is happening
-
University of Houston
Houston, United States Active
Researchers
- Principal investigator: Coulson-Thomas, Vivien Jane — University of Houston
- Study coordinator: Coulson-Thomas, Vivien Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.