Ocular surface diagnostics and care plans to improve cataract surgery results

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This program is a longitudinal, interventional effort with parallel groups designed to clarify how ocular surface disease affects cataract surgery outcomes and to test management algorithms. Phase 1A enrolls a small cohort to determine the impact of moderate dry eye in at-risk patient groups, and Phase 1B expands to a larger cohort to compare outcomes across different intraocular lens (IOL) types. The work uses advanced tear-film and corneal imaging alongside standardized dry eye criteria and treatment pathways, with follow-up of postoperative visual and satisfaction measures. Results will be used to propose practical preoperative diagnostic and management protocols for the ocular surface.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below):

  1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\]
  2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye

Inclusion criteria to fulfil all for controls (patients w/o dry eye):

1. DEQ5 \<=6.
2. Staining \< grade 1 in at least one corneal zone.
3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months.
4. No visible punctal plugs.

Exclusion Criteria:

* If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease
* Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis
* Intraocular surgery within the previous 6 months
* Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months
* Central nervous system and hormonal drugs required within the last month and during the study
* Active ocular infection, inflamed chalazion, or presence of pterygium
* Glaucoma which requires topical anti-glaucoma medications
* Any need to wear contact lens during the study
* Having issues which make it difficult to follow up (eg., wheelchair, etc)
* Pregnant and breast-feeding woman

Where it's running

• Singapore Eye Research Institute
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Louis Tong, PhD — Singapore Eye Research Institute
• Study coordinator: Louis Tong, PhD
• Email: louis.tong.h.t@singhealth.com.sg
• Phone: 65767200

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Effect of Dry Eye Treatment on Corneal Astigmatism Measurements

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.