Detecting severe dry eye and improving its treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators will use a prototype AI algorithm to analyze a single corneal photograph taken after dye staining to identify central corneal staining associated with severe dry eye. Adults previously diagnosed with dry eye will complete the DEQ-5 symptom questionnaire and undergo standardized eye examinations and corneal imaging at the Singapore Eye Research Institute. The AI results will be compared with DEQ-5 screening to see if adding or replacing the questionnaire improves identification of cases that require specialist prescription therapies such as cyclosporine. The study aims to reduce unnecessary hospital referrals and support sustainable community-based management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 21 years old and above
2. Participants must be previously diagnosed with dry eye in the dry eye clinic (previous referred and had various forms of treatment such as artificial tears or prescription eyedrops)
3. Willing to perform all eye examinations and questionnaires in this study
4. Ability to provide informed consent

Exclusion Criteria:

1. All subjects meeting any of the exclusion criteria at baseline will be excluded from participation and then list the criterion.
2. Any other specified reason as determined by clinical investigator

Where it's running

• Singapore Eye Research Institute
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Louis Tong — Singapore Eye Research Institute (SERI)
• Study coordinator: Sharon Yeo, BSc
• Email: sharon.yeo.w.j@singhealth.com.sg
• Phone: 65767200

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.