Investigating the role of corneal nerves in dry eye disease
Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms
This study looks at how the nerves in the eye relate to dry eye symptoms to see if they can help explain why some people have worse dry eye than others.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Applied Sciences and Arts Northwestern Switzerland Academic / other |
| Locations | 1 site (Olten) |
| Trial ID | NCT06841471 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between corneal nerve function and morphology with tear film instability and the loss of ocular surface homeostasis in patients with dry eye disease (DED). It will assess how these factors may differ based on the severity of dry eye symptoms. Participants will be divided into two groups: those diagnosed with DED and those without. The study will involve careful measurement and observation of corneal nerve characteristics in relation to dry eye conditions.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with dry eye disease as well as those without the condition for comparative analysis.
Not a fit: Patients with systemic diseases affecting ocular health or those who have had prior eye surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of dry eye disease and lead to improved diagnostic and treatment strategies for patients.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have indicated a correlation between corneal nerve health and dry eye symptoms.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Group with DED: Diagnosis of DED based on the TFOS DEWS II report * Group without DED: No diagnosis of DED Exclusion Criteria: * Exclusion criteria: * Systemic disease that may affect ocular health and innervation * injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology * regular application of systemic or ocular medication known to affect the tear film except from DED medications * eye drops or makeup on the day of measurement. Remarks: Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment. Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination
Where this trial is running
Olten
- Institute of Optometrym FHNW — Olten, Switzerland (Recruiting)
Study contacts
- Study coordinator: Daniela S Nosch, BSc MSc PhD
- Email: daniela.nosch@fhnw.ch
- Phone: 41629572603
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.