Investigating the role of corneal nerves in dry eye disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between corneal nerve function and morphology with tear film instability and the loss of ocular surface homeostasis in patients with dry eye disease (DED). It will assess how these factors may differ based on the severity of dry eye symptoms. Participants will be divided into two groups: those diagnosed with DED and those without. The study will involve careful measurement and observation of corneal nerve characteristics in relation to dry eye conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Group with DED: Diagnosis of DED based on the TFOS DEWS II report
* Group without DED: No diagnosis of DED

Exclusion Criteria:

* Exclusion criteria:
* Systemic disease that may affect ocular health and innervation
* injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
* regular application of systemic or ocular medication known to affect the tear film except from DED medications
* eye drops or makeup on the day of measurement.

Remarks:

Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment.

Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination

Where it's running

• Institute of Optometrym FHNW
  Olten, Switzerland Recruiting

Study contacts

• Study coordinator: Daniela S Nosch, BSc MSc PhD
• Email: daniela.nosch@fhnw.ch
• Phone: 41629572603

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.