Autologous Serum Eye Drops for Severe Dry Eye: Protein Factors and Response

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial examines whether differences in the protein composition of autologous serum eye drops are linked to how patients with severe dry eye respond to treatment. Participants are adults with refractory dry eye who have not previously used autologous serum and are being treated at Saint-Etienne University Hospital. Data collected from medical records will be analyzed to identify protein factors associated with clinical response. The study focuses on exploring biological markers that may predict benefit from autologous serum therapy. No randomization or placebo is described, and the approach emphasizes observational data alongside the serum treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years
* Patients with severe dry eye with an Oxford score \> 1
* Patients with dry eye syndrome refractory to conventional treatments: tear substitutes, immunosuppressive eye drops or corticosteroids.
* AS-naïve patients followed by an ophthalmologist at Saint-Etienne University Hospital
* Patients affiliated to or entitled under a social security scheme
* Patients who have received informed information about the study

Exclusion Criteria:

* Severe ocular dryness due to a genetic disease
* Patients not under the care of an ophthalmologist at Saint-Etienne University Hospital.
* Patients not eligible for treatment with AS (pregnant women, anaemia, current infection, progressive disease, serological results contraindicating blood sampling).
* Patients under protective measures

Where it's running

• CHU de Saint-Etienne
  Saint-Etienne, France Recruiting

Study contacts

• Principal investigator: Elodie JACQUEROUX, MD — CHU de Saint-Etienne
• Study coordinator: Elodie JACQUEROUX, MD
• Email: Elodie.Jacqueroux@chu-st-etienne.fr
• Phone: (0)477828070

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.