Understanding pain and light sensitivity in migraine and dry eye conditions
Mechanisms of Pain and Photophobia in Migraine and Dry Eye
This study is looking into why people with migraines and dry eye often feel pain and sensitivity to light, hoping to find new ways to help treat these uncomfortable symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10913444 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind ocular pain and photophobia, which are common symptoms in migraine and dry eye disease. By studying the trigeminal nerve and its role in regulating sensations in the eye, the research aims to uncover how these conditions are linked and how they can be treated. Using rodent models, the team will explore the molecular and neural pathways involved, focusing on potential therapeutic targets that could lead to new treatments. The goal is to better understand the underlying causes of these debilitating symptoms and identify effective non-opioid therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing chronic ocular pain, photophobia, or those diagnosed with migraine or dry eye disease.
Not a fit: Patients without symptoms of migraine or dry eye disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for patients suffering from migraine and dry eye disease.
How similar studies have performed: Previous research has shown promise in understanding the role of the trigeminal nerve in pain conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Aicher, Sue a — Oregon Health & Science University
- Study coordinator: Aicher, Sue a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.