Personalized immune care for critically ill children with sepsis
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site
Funded at Central Michigan University · NIH-11557270 · Data updated 2026-11-12
A multi-center effort uses rapid immune-phenotype tests to tailor treatments for children with sepsis-related organ failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $143,916 |
| NIH project number | 3RL1HD107773-05S1 |
| Project ID | NIH-11557270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 who are admitted with sepsis and organ dysfunction across multiple pediatric centers.
✕Less likely to help
Patients whose sepsis does not involve MODS or who do not meet specific immune-phenotype criteria may not benefit from the personalized approach.
What this research studies
This project builds on a network that coinsiders how severely ill children with sepsis respond to different therapies. It has developed quick tests to identify each child’s immune profile and is using that information to guide personalized treatment plans. The effort involves multiple pediatric centers collecting data and applying protocols aimed at improving outcomes for kids with sepsis-induced MODS. The focus is on making care more precise for each child rather than relying only on standard guidelines.
Why it matters
Potential benefit: If successful, children with sepsis-related organ failure could receive more effective, individualized treatments that improve survival and recovery.
How similar studies have gone: Preliminary data from CPCCRN studies suggest that phenotype-guided care can influence outcomes, but this approach is still being tested in pediatrics.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Meert, Kathleen L. — Central Michigan University
- Study coordinator: Meert, Kathleen L.
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.