Personalized immune-based care for septic kids with organ failure
Official title: Collaborative Pediatric Critical Care Research Network (CPCCRN)
Funded at University of Pittsburgh at Pittsburgh · NIH-11563902 · Data updated 2026-11-12
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $157,707 |
| NIH project number | 3RL1HD107779-05S1 |
| Project ID | NIH-11563902 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 who are admitted with sepsis and organ dysfunction may be eligible.
✕Less likely to help
Children without sepsis or with stable conditions are unlikely to benefit; those not meeting specific immune-phenotype criteria may not.
What this research studies
The CPCCRN aims to use precision medicine to guide treatment for septic children across multiple hospitals. The project has built a lab and data pipeline to identify specific immune system patterns and apply targeted care. If successful, this approach could change how clinicians treat pediatric sepsis by moving beyond one-size-fits-all protocols.
Why it matters
Potential benefit: Children with sepsis-induced organ failure could receive more effective, personalized treatments.
How similar studies have gone: Previous multi-center pediatric trials have shown feasibility of standardized data collection and phenotype-guided care, with ongoing PRECISE study building on these methods.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Carcillo, Joseph a — University of Pittsburgh at Pittsburgh
- Study coordinator: Carcillo, Joseph a
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Network study
A national network is testing personalized immune treatments for critically ill children with sepsis in multiple hospitals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.