Personalized care for septic children through immunomodulation in MODS
Official title: Collaborative Pediatric Critical Care Research Network (CPCCRN)
Funded at Children's Hosp of Philadelphia · NIH-11564076 · Data updated 2026-11-12
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $175,999 |
| NIH project number | 3RL1HD107777-05S1 |
| Project ID | NIH-11564076 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with sepsis-induced MODS who have distinct immune phenotypes identified by the study’s diagnostic tools.
✕Less likely to help
Some children may not have an actionable immune phenotype or may not be eligible for the personalized interventions.
What this research studies
The CPCCRN consortium collects data from many seriously ill children with sepsis across multiple centers and has developed tests to identify each child’s immune state. The PRECISE study will use these immune profiles to guide personalized treatment plans, aiming to improve outcomes beyond standard antibiotics and supportive care. Researchers will employ rapid laboratory diagnostics to classify immune phenotypes and then apply targeted interventions accordingly. Families of eligible children may be asked to participate in observational data collection and, if applicable, interventional protocols under the study’s approved guidelines.
Why it matters
Potential benefit: If successful, this approach could lead to more effective, personalized therapies for children with sepsis-related organ failure, potentially reducing mortality and long-term complications.
How similar studies have gone: Preliminary data suggest immune-phenotype-guided strategies can influence outcomes, but large-scale confirmation is needed.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Berg, Robert Allen — Children's Hosp of Philadelphia
- Study coordinator: Berg, Robert Allen
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Network study
A national network is testing personalized immune treatments for critically ill children with sepsis in multiple hospitals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.