Helping children with severe infections in critical care
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site
Funded at Utah State Higher Education System--University of Utah · NIH-11170738 · Data updated 2026-11-12
This effort aims to understand and improve how children fight severe infections, called sepsis, in the hospital.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 13, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $91,767 |
| NIH project number | 5PL1HD105462-05 |
| Project ID | NIH-11170738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years old who are hospitalized with severe infections leading to sepsis and multiple organ dysfunction may be candidates.
✕Less likely to help
Patients who do not have sepsis or are outside the specified age range would not directly benefit from this particular research.
What this research studies
When children get very sick from an infection, it can lead to a life-threatening condition called sepsis, where their organs may start to fail. This work is part of a larger network focused on finding better ways to care for critically ill children. Researchers plan to conduct a trial to see if personalized treatments can help children with sepsis by improving their ability to fight infection and control inflammation. They will collect blood samples from children with sepsis to learn more about their immune responses.
Why it matters
Potential benefit: If successful, this work could lead to new, personalized treatments that save the lives of children suffering from severe sepsis and organ failure.
How similar studies have gone: This approach explores new technologies for personalized immunomodulation, representing a novel strategy for a condition where past treatments have had limited success.
Where this research is happening
-
Utah State Higher Education System--University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Carcillo, Joseph a — Utah State Higher Education System--University of Utah
- Study coordinator: Carcillo, Joseph a
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.