MUSIC Consortium: A pathway to precision care for ARDS and critical illness
Official title: The MUltidimenSional phenotyping In Critical care (MUSIC) Consortium: A pathway to precision medicine at the bedside
Funded at Vanderbilt University Medical Center · NIH-11321096 · Data updated 2026-11-12
A large, multi-site study will profile biological signals in adults with ARDS and related critical illnesses to guide personalized care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $708,263 |
| NIH project number | 5U01HL168412-04 |
| Project ID | NIH-11321096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with ARDS, pneumonia, or sepsis who are enrolled in participating centers.
✕Less likely to help
Patients not meeting the criteria or not enrolled in participating sites may not benefit from the findings.
What this research studies
This project creates a nationwide observational cohort of about 5,000 critically ill patients to map biological phenotypes and how they respond to care decisions. It uses advanced data collection and long-term follow-up to link biological markers with outcomes. By identifying hyper- and hypo-inflammatory patterns, the team aims to tailor treatments like fluids, ventilator settings, and specific drugs to the patient’s biology. The ultimate goal is to move beyond one-size-fits-all treatment toward precision, bedside-friendly decisions for ARDS, pneumonia, and sepsis.
Why it matters
Potential benefit: If successful, patients with ARDS and related critical illnesses could receive more personalized therapies that improve outcomes and reduce complications.
How similar studies have gone: Previous studies have shown that biological phenotypes in ARDS can predict differential responses to care and treatments.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Ware, Lorraine B — Vanderbilt University Medical Center
- Study coordinator: Ware, Lorraine B
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
-
Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
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-
Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
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-
Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
-
Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
-
Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.