Collaborative Pediatric Critical Care Network study
Official title: Collaborative Pediatric Critical Care Research Network
Funded at Utah State Higher Education System--University of Utah · NIH-11562837 · Data updated 2026-11-12
A national network is testing personalized immune treatments for critically ill children with sepsis in multiple hospitals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 13, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,386,195 |
| NIH project number | 3PL1HD105462-05S1 |
| Project ID | NIH-11562837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with sepsis-induced MODS who meet specific immune profile criteria and are treated at participating centers.
✕Less likely to help
Children without sepsis or MODS or who do not meet the immune-phenotype criteria may not benefit from these interventions.
What this research studies
This grant supports a large, multi-site effort in pediatric critical care to study how targeted immune therapies might help children with sepsis-related organ failure. The project builds a diverse network of clinical sites and ancillary sites to enroll and monitor patients, using immunophenotype-guided approaches. Two concurrent, placebo-controlled trials will test whether individualized immune modulation improves outcomes for kids with sepsis-induced MODS. The work leverages prior findings that specific immune profiles can be identified and that immune-boosting strategies may reverse immunosuppression.
Why it matters
Potential benefit: If successful, the research could lead to more effective, personalized treatments for severely ill children with sepsis.
How similar studies have gone: Prior studies have shown identifiable immune phenotypes and potential reversal of immunosuppression with GM-CSF in similar pediatric populations.
Where this research is happening
-
Utah State Higher Education System--University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Watt, Kevin M — Utah State Higher Education System--University of Utah
- Study coordinator: Watt, Kevin M
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.