Personalized immunomodulation for septic children in the ICU
Official title: Collaborative Pediatric Critical Care Research Network (CPCCRN)
Funded at University of California, San Francisco · NIH-11560824 · Data updated 2026-11-12
A pediatric critical care network is testing a personalized treatment approach for kids with sepsis-related organ failure to improve outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $148,925 |
| NIH project number | 3RL1HD107786-05S1 |
| Project ID | NIH-11560824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 who are admitted with sepsis and organ dysfunction in participating centers.
✕Less likely to help
Children without sepsis or without MODS may not receive direct benefit.
What this research studies
This grant supports a multi-center, pediatric-focused program that identifies immune patterns in septic children and uses rapid laboratory diagnostics to guide individualized care. It aims to move beyond one-size-fits-all sepsis treatment by tailoring interventions to each child’s immune status. The study builds infrastructure to diagnose phenotypes quickly and test targeted care protocols across hospitals. The work is grounded in data from numerous children with sepsis across several centers, and it seeks to translate immune profiling into actionable treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment for children with septic shock and MODS, potentially reducing deaths and long-term complications.
How similar studies have gone: Previous work shows distinct immune phenotypes in septic children, supporting a personalized approach, with ongoing exploration of targeted interventions.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Mcquillen, Patrick Sean — University of California, San Francisco
- Study coordinator: Mcquillen, Patrick Sean
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
-
Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.