Children's National pediatric critical care network site
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site
Funded at Children's Research Institute · NIH-11179468 · Data updated 2026-11-12
This project tests new treatments and care approaches to help critically ill children (ages 0–11), especially those with sepsis and multiple organ failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $178,032 |
| NIH project number | 5RL1HD107781-05 |
| Project ID | NIH-11179468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children from birth through age 11 who are admitted to a participating pediatric intensive care unit, especially those with sepsis or multiple organ dysfunction, are the main candidates.
✕Less likely to help
Children who are not critically ill, are older than 11, or are cared for outside participating hospitals would not be eligible and are unlikely to benefit directly from this network.
What this research studies
This effort joins Children’s National Hospital with 22 other pediatric centers to enroll enough children for studies of critical illnesses like sepsis and multi-organ failure. Teams at Children’s National and partner sites will enroll children admitted to the pediatric ICU, collect clinical information and biological samples when appropriate, and follow recovery and outcomes. By combining patients across many hospitals, the network can run larger clinical trials and observational studies that single hospitals cannot do alone. The work builds on prior CPCCRN cycles and aims to turn promising ideas into treatments that can be used in routine pediatric ICU care.
Why it matters
Potential benefit: If successful, this work could improve survival and recovery for children with severe infections and multi-organ failure and speed delivery of better ICU care.
How similar studies have gone: Previous CPCCRN cycles and other multicenter pediatric critical care efforts have enabled successful trials and improved understanding, though many specific therapies remain unproven in children.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Shein, Steven — Children's Research Institute
- Study coordinator: Shein, Steven
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.