Collaborative Pediatric Critical Care Network: Clinical Site
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site
Funded at Research Inst Nationwide Children's Hosp · NIH-11561444 · Data updated 2026-11-12
A nationwide network study aims to tailor sepsis treatment for children with organ failure based on each child’s immune profile.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $153,999 |
| NIH project number | 3RL1HD107783-05S1 |
| Project ID | NIH-11561444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years with sepsis and organ dysfunction admitted to participating pediatric centers.
✕Less likely to help
Children without sepsis or without involvement of the immune-phenotype guided interventions may not benefit.
What this research studies
This grant supports a pediatric critical care network that works across multiple hospitals to run patient-centered trials and observational studies. The PRECISE study explores personalized immunomodulation for kids with sepsis-induced organ dysfunction, using rapid immune-phenotype tests to guide treatment. By coordinating data and samples from many centers, it seeks to implement personalized care approaches in real-world clinical settings. The project builds the infrastructure to diagnose immune phenotypes quickly and test targeted interventions to improve outcomes for severely ill children.
Why it matters
Potential benefit: If successful, personalized treatment strategies could reduce organ failure and save lives in critically ill children.
How similar studies have gone: Previous multi-center pediatric sepsis studies have shown feasibility of standardized data collection and rapid biomarker-based phenotyping; this builds on that groundwork with a personalized treatment approach.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Hall, Mark W — Research Inst Nationwide Children's Hosp
- Study coordinator: Hall, Mark W
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.