Understanding Sepsis in Critically Ill Children
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site
Funded at University of Pittsburgh at Pittsburgh · NIH-11180282 · Data updated 2026-11-12
This project helps us learn more about how to treat children who get very sick with infections, especially sepsis, to help them recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $157,707 |
| NIH project number | 5RL1HD107779-05 |
| Project ID | NIH-11180282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years old who are critically ill with sepsis may be candidates for future participation.
✕Less likely to help
Patients who are not children, do not have sepsis, or are not critically ill would not directly benefit from this specific research.
What this research studies
This grant establishes two hospitals, UPMC Children’s Hospital of Pittsburgh and Mercy Children’s Hospital Kansas City, as part of a larger network focused on critically ill children. The first major effort will be a study on sepsis, a severe infection where the body's response can harm organs. We will collect blood samples from children with sepsis to understand how their immune system is fighting the infection and managing inflammation. This information will help us explore new ways to personalize treatments and improve their chances of survival.
Why it matters
Potential benefit: If successful, this work could lead to more effective, personalized treatments for children with sepsis, potentially saving lives and improving recovery.
How similar studies have gone: This approach uses new technology to temper the body's response to sepsis, representing a novel strategy not previously available.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Carcillo, Joseph a — University of Pittsburgh at Pittsburgh
- Study coordinator: Carcillo, Joseph a
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.