Personalized immunomodulation for septic children in critical care
Official title: Collaborative Pediatric Critical Care Research Network (CPCCRN)
Funded at University of Michigan at Ann Arbor · NIH-11553794 · Data updated 2026-11-12
A national network is testing tailored treatments for kids with sepsis-related organ failure to see if personalized care improves outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $156,000 |
| NIH project number | 3RL1HD107776-05S1 |
| Project ID | NIH-11553794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 with sepsis-induced MODS who are admitted to participating pediatric ICUs.
✕Less likely to help
Not all children with sepsis will have the identified immune profiles or respond to personalized protocols.
What this research studies
This initiative gathers data from many pediatric ICU patients with sepsis-induced MODS to identify distinct immune profiles. It has built a lab workflow to rapidly diagnose these profiles and plans interventional protocols that tailor treatment to the child's biology. The goal is to move beyond one-size-fits-all care by matching therapies to each patient’s immune status in real time.
Why it matters
Potential benefit: If successful, children with septic shock and organ dysfunction could receive more precise treatments that improve recovery and survival.
How similar studies have gone: Prior work in pediatric sepsis has shown immune phenotypes; this program aims to translate that into personalized interventional care.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Mourani, Peter Michael — University of Michigan at Ann Arbor
- Study coordinator: Mourani, Peter Michael
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.