Metabolic testing to improve care for sepsis and ARDS
Translational Metabolomics in Critical Care
This work uses blood metabolic testing to find patterns that could help doctors predict outcomes and tailor care for adults with sepsis and ARDS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11263712 on NIH RePORTER |
What this research studies
Researchers analyze small molecules in blood (metabolites) from people with sepsis and ARDS and from laboratory swine models to find metabolic patterns linked to outcomes. They use advanced tools like liquid chromatography–mass spectrometry, quantitative NMR, and novel point-of-care devices to measure metabolites in clinical and experimental samples. The team compares results from animal models and human sepsis cohorts and studies relationships with angiopoietin-2 levels to validate findings. The aim is to develop faster metabolic signatures that could help guide treatment decisions in the ICU.
Who could benefit from this research
Good fit: Adults hospitalized with sepsis or acute respiratory distress syndrome, especially those treated at participating ICUs or enrolled in the program's clinical cohorts, are the ideal candidates.
Not a fit: People without sepsis or ARDS, pediatric patients if the work focuses on adults, and patients not treated at participating hospitals are unlikely to receive direct benefit.
Why it matters
Potential benefit: Could lead to faster blood tests that predict who will worsen and help personalize treatment for sepsis and ARDS patients.
How similar studies have performed: Prior metabolomics studies have found promising biomarker patterns in sepsis and ARDS, but turning those findings into routine clinical tests is still early and developing.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Stringer, Kathleen a — University of Michigan at Ann Arbor
- Study coordinator: Stringer, Kathleen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.