Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
Official title: Collaborative Pediatric Critical Care Research Network (CPCCRN)
Funded at Children's Research Institute · NIH-11564141 · Data updated 2026-11-12
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $178,032 |
| NIH project number | 3RL1HD107781-05S1 |
| Project ID | NIH-11564141 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years with sepsis-induced MODS who are treated in participating centers.
✕Less likely to help
Children without sepsis-related organ dysfunction or not admitted to participating centers may not benefit.
What this research studies
This project centers on children with severe sepsis who may develop organ dysfunction. Researchers have built a rapid testing lab to identify specific immune patterns in each patient and to guide tailored treatment plans. The study coordinates care across multiple pediatric centers and uses data from real cases to pilot personalized protocols. The goal is to move beyond one-size-fits-all care toward strategies that match a child’s biology to the right therapy.
Why it matters
Potential benefit: If successful, this work could lead to more effective, individualized treatments for critically ill children with sepsis.
How similar studies have gone: Previous work shows distinct immune profiles in septic children, supporting the potential for personalized approaches.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Shein, Steven — Children's Research Institute
- Study coordinator: Shein, Steven
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
-
Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Network study
A national network is testing personalized immune treatments for critically ill children with sepsis in multiple hospitals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.