Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site
Funded at Children's Hospital of Los Angeles · NIH-11563565 · Data updated 2026-11-12
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $169,500 |
| NIH project number | 3RL1HD107785-05S1 |
| Project ID | NIH-11563565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years with sepsis-associated organ dysfunction who are treated at participating centers.
✕Less likely to help
Some children may not experience direct benefit if their sepsis does not match the study’s identified phenotypes or if they are not enrolled.
What this research studies
This grant supports a network of hospitals working together to test personalized treatments for children with sepsis-related organ failure. It builds on PRECISE, a study that identifies immune system differences in septic children and uses rapid diagnostics to tailor therapy. The project aims to move from standard one-size-fits-all treatment toward care guided by each child’s biology, using data from multiple centers in real time. If successful, it could lead to more effective, individualized interventions and better survival and recovery for young patients.
Why it matters
Potential benefit: Potentially better, personalized treatments could improve survival and reduce organ damage in septic children.
How similar studies have gone: Prior work in CPCCRN has shown the feasibility of multi-center pediatric sepsis research and phenotype-guided approaches, with promising signals for personalized care.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Khemani, Robinder — Children's Hospital of Los Angeles
- Study coordinator: Khemani, Robinder
Related research
Other NIH-funded projects on the same topics.
-
Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
-
Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
-
Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
-
Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
-
Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
-
Collaborative Pediatric Critical Care Network study
A national network is testing personalized immune treatments for critically ill children with sepsis in multiple hospitals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.