Intersection of a vascular pathway with blood pressure control
Official title: Intersection of the PPARγ-RhoBTB1-Cullin-3 Pathway and Renin-Angiotensin System in Blood Pressure, Vascular Function and Arterial Stiffness
Funded at Medical College of Wisconsin · NIH-11321576 · Data updated 2026-11-12
A study in adults will look at how a specific protein pathway in blood vessels affects blood pressure, arterial stiffness, and vascular function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2032 |
| Funding year | 2026 |
| Award (this year) | $1,070,160 |
| NIH project number | 5R35HL177123-02 |
| Project ID | NIH-11321576 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ with or at risk for hypertension or vascular dysfunction.
✕Less likely to help
Individuals without hypertension or arterial stiffness issues may not directly benefit from this pathway-focused research.
What this research studies
This project focuses on adults with high blood pressure or related vascular concerns. It will explore how the PPARγ-RhoBTB1-Cullin-3 pathway influences nitric oxide availability and how smooth muscle cells respond to signals from the endothelium. Researchers will use molecular and physiological methods to map how this pathway contributes to BP regulation and arterial stiffness, aiming to identify targets to improve vascular health. The work could lead to strategies that rapidly improve arterial function and blood pressure control.
Why it matters
Potential benefit: If successful, the findings could lead to new ways to lower blood pressure and reduce cardiovascular risk by targeting arterial function.
How similar studies have gone: Prior work suggests that similar regulatory circuits can modulate NO signaling and vascular tone, though this exact pathway has not been fully tested in humans.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Sigmund, Curt Daniel — Medical College of Wisconsin
- Study coordinator: Sigmund, Curt Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.