Vitamin K2 for adults with episodic migraine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with episodic migraine who meet eligibility will be recruited from the neurology clinic at Lebanese American University Medical Center–Rizk Hospital and given either vitamin K2 (menaquinone‑7) or a placebo. Participants will complete a baseline migraine diary and be followed to compare changes in migraine attack frequency and measures of arterial stiffness. The trial targets people with 4–14 migraine days per month and excludes those on standard migraine prevention or with other primary headache disorders. Vascular outcomes are motivated by prior findings that vitamin K2 can reduce arterial stiffness in other patient groups, while migraine outcomes address a largely under‑explored nutritional approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or above
* History of episodic migraine with or without aura since \> 12 months according to the ICHD-3 criteria.
* Migraine frequency from 4-14 days per month over the 3 months prior to screening.
* Migraine frequency from 4-14 days per month during the baseline period of assessment.
* Successful completion of the migraine diary during the baseline evaluation period.

Exclusion Criteria:

* Migraine patients with superimposed tension type or other forms of primary headaches
* Patients who are currently on any of the migraine prophylactic treatments (Sodium valproate, Topiramate, Beta-blockers, Tricyclic antidepressants, SRNI, Flunarizine, Verapamil, Lisinopril, Candesartan)
* Patients who have been on any of the previously listed medications within 3 months of screening
* Patient who takes the following medications:

  * Ergotamine or Triptans \> 10 days per month
  * NSAIDs or paracetamol \> 15 days per month
  * Opioids more than 4 days per month
  * Patients on anticoagulants
* Other active chronic pain syndromes (i.e. fibromyalgia, painful peripheral neuropathy, post-herpetic neuralgia…)
* History of hypersensitivity to the vitamin K2
* History of soy protein, cheese, eggs and meat allergy
* History of thrombotic events
* Diagnosed coagulopathy or any condition related to coagulation
* Cardiovascular event in the past month
* Current or planned pregnancy
* Lactation
* Inability to tolerate oral medications
* Known intestinal malabsorption or hypomotility syndromes
* Atrial fibrillation
* Active malignancy
* Any acute illness in the past month

Where it's running

• Lebanese American University Medical Center - Rizk Hospital
  Beirut, Beirut, Lebanon Recruiting

Study contacts

• Principal investigator: Sola Aoun Bahous, MD, PhD — Lebanese American University School of Medicine
• Study coordinator: Sola Aoun Bahous, MD, PhD
• Email: sola.bahous@lau.edu.lb
• Phone: +9613259450

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.