Can mouth health and chewing help explain arterial stiffness in healthy adults
Official title: Oral Structural and Functional Profile as an Additive Biomarker for Explaining Central Arterial Stiffness in the INN.HEALTH Cohort
Run by VASCage GmbH · NCT07736222 · Data updated 2026-11-12
This study tests whether a profile of oral health and function adds information about central arterial stiffness beyond traditional risk factors in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 750 (estimated) |
| Sponsor | VASCage GmbH Academic / other |
| Locations | 1 site (Innsbruck, Tyrol) |
| Status | Recruiting |
| Started | July 8, 2026 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | July 30, 2026 |
| Trial ID | NCT07736222 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) in the INN.HEALTH cohort living in Innsbruck City or Innsbruck-Land who can safely perform the oral tests and give consent.
✕Probably not a fit
Participants with temporomandibular disorders, active dental treatment, or inability to safely chew/swallow the test materials may not benefit from this specific assessment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
INN.oral.HEALTH is a cross-sectional sub-study within the INN.HEALTH prevention cohort in Innsbruck. It adds standardized assessments of oral structure and function to see if they improve understanding of central arterial stiffness, measured by carotid‑femoral pulse wave velocity. The study compares a base cardiovascular model with an extended model that includes the oral test battery. It examines whether oral health, chewing, and tongue strength contribute additional explanatory value for vascular aging beyond known risk factors.
Why it matters
Potential benefit: If successful, it could help identify additional, non-traditional factors related to arterial stiffness and inform broader prevention strategies that include oral health.
How similar studies have gone: Previous research has linked oral health indicators with general health and vascular aging, but the incremental explanatory value in this preventive setting remains to be established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adults meeting the INN.HEALTH cohort eligibility criteria, including age ≥18 years, residence in Innsbruck City or Innsbruck-Land, and capacity to consent * additionally at Visit 4, participants must report being able to safely chew and, where required, swallow the standardized test materials Exclusion Criteria: * temporalmandibular joint disorders * severe jaw joint complaints * active dental treatment at the time of assessment * inability to safely chew/swallow the standardized test materials.
Where it's running
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VASCage Study Site
Innsbruck, Tyrol, Austria Recruiting
Study contacts
- Principal investigator: Petr Simurda, MD — VASCage GmbH
- Study coordinator: Simon Sollereder, MSc
- Email: simon.sollereder@vascage.at
- Phone: +43 664 1004838
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.