Condition

Oxidative Stress clinical trials and research

• 32Clinical trials
• 150NIH research projects
• 1New in 30 days
• 15Countries

Newest Oxidative Stress clinical trials

All recruiting trials (32)

• Diabetes, Dementia, and Oxidative Stress: A look at Nox2-related markers

  This study tests whether oxidative stress linked to Nox2 is related to dementia risk in adults with type 2 diabetes.

  Recruiting Neuromed IRCCS · Pozzilli · NCT07928453

• Opioid-Free vs Opioid-Based Anesthesia for Thyroid Surgery

  This study tests whether a non-opioid anesthesia approach can match or improve outcomes for adults undergoing thyroidectomy.

  Recruiting Malatya Egitim Ve Arastirma Hastanesi · Malatya · NCT07864155

• Training to reduce oxidative stress in knee OA

  A six-week program compares supervised knee-strengthening training with a daily 6,000-step walking plan to see if it improves pain, function, and blood markers of cellular stress in people with knee osteoarthritis.

  Recruiting Vrije Universiteit Brussel · Capelle aan den IJssel · NCT07845838

• Ashwagandha with resistance training to boost strength and stress markers

  This 12-week study tests whether taking ASHWAGANDHA along with regular resistance training helps healthy, trained men see improvements in strength, stress levels, sleep, and cognitive function compared with a placebo.

  Recruiting Gdansk University of Physical Education and Sport · Gdansk, Pomeranian Voivodeship · NCT07803068

• Oxidative Stress and Heart Risk in People with Rheumatoid Arthritis

  This study tests whether certain markers of oxidative stress in people with rheumatoid arthritis are linked to subclinical atherosclerosis and arterial stiffness, which could relate to future heart disease risk.

  Recruiting University of La Laguna · Santa Cruz de Tenerife, Canary Islands · NCT07760662

• NVTIA Ergothioneine for Healthy Aging and Skin Health

  This study tests whether taking NVTIA Ergothioneine daily for 12 weeks helps healthy adults age more gracefully and keeps skin looking and feeling better compared with a placebo.

  Recruiting European Life Science Research Association · Dhaka · NCT07750002

• Pumpkin seed oil for people on hemodialysis

  This study tests whether taking pumpkin seed oil daily for 3 months helps reduce inflammation and improve-related lab markers in people with end-stage kidney disease on dialysis.

  Recruiting Al-Mustansiriyah University · Baghdad, Karkh · NCT07710183

• Hyperuricemia and gum disease: is uric acid linked to bone loss in periodontitis?

  This observational study tests whether high uric acid levels are related to periodontitis and alveolar bone loss in adults.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07666126

• Post-Exercise Hyperoxia for Recovery in Cyclists

  This study tests whether breathing higher-oxygen air in a pressurized chamber after a hard cycling effort helps competitive cyclists recover and perform better the next day.

  Recruiting Université Catholique de Louvain · Louvain-la-Neuve, Brabant-Wallon · NCT07659301

• Hyaluronic Acid Added to Gum Therapy for Smokers with Periodontal Disease

  This study tests whether applying hyaluronic acid gel after non-surgical gum cleaning helps smokers with periodontitis heal better than cleaning alone.

  Recruiting Marmara University · Istanbul · NCT07597213

• Red propolis supplementation for people with chronic kidney disease

  This study tests whether taking red propolis daily for 8 weeks can reduce inflammation and oxidative stress in people with chronic kidney disease who are managed without dialysis.

  Recruiting Universidade Federal Fluminense · Rio de Janeiro, Rio de Janeiro · NCT07597005

• Ginger capsules for inflammation, oxidative stress, and blood vessel health

  This trial will test whether taking a daily ginger capsule for 60 days can lower inflammation and oxidative stress and improve blood vessel function in adults with excess body fat.

  Recruiting Universidad Católica San Antonio de Murcia · Murcia, Murcia · NCT07437222

• Daily gazpacho to improve semen quality in men with reduced sperm parameters

  This study will test whether drinking a daily 330 mL serving of gazpacho for 12 weeks helps men with reduced sperm quality improve their semen parameters and lower oxidative stress.

  Recruiting Ginefiv · Madrid, Madrid · NCT07375238

• Haskap berries for faster recovery after intense resistance workouts

  This tests whether drinking Haskap berry juice helps resistance-trained adults recover faster from intense lower-body workouts by lowering inflammation and oxidative stress.

  Recruiting Montana State University · Bozeman, Montana · NCT07344727

• Monitoring blood markers during DIEP flap breast reconstruction

  We will see if measuring inflammation and oxidative stress markers in blood before and during the first 72 hours after DIEP flap reconstruction helps map recovery patterns for women having immediate breast reconstruction after mastectomy.

  Recruiting Hubei Cancer Hospital · Wuhan, Hubei · NCT07263347

• Mitochondrial oxidative stress and blood vessel health in young adults with early life adversity

  We will test whether taking the mitochondrial antioxidant MitoQ can improve blood vessel function in healthy 18–29-year-olds who experienced significant adverse events in childhood.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07244809

• Isoflurane versus sevoflurane effects on oxidative stress during laparoscopic gallbladder removal

  This trial will test whether isoflurane or sevoflurane causes different levels of oxidative stress in adults having elective laparoscopic gallbladder removal.

  Recruiting Ain Shams University · Cairo · NCT07152912

• Different root canal sealers and salivary oxidative stress in chronic apical periodontitis.

  This test will compare two types of root canal sealers to see if they change saliva oxidative stress markers in adults with chronic apical periodontitis.

  Recruiting Ordu University · Ordu, Ordu- Altınordu · NCT07059481

• Pterostilbene, silybin, and nicotinamide riboside supplement for exercise-related oxidative stress

  The study will test whether taking a daily supplement that combines pterostilbene, silybin, and nicotinamide riboside reduces oxidative stress after intense exercise in healthy, active men.

  Recruiting Fundació Eurecat · Reus, Tarragona · NCT07024966

• Blood and OCT biomarkers in people with diabetic macular edema receiving anti-VEGF or dexamethasone implant

  This project will test whether blood markers and OCT imaging signs can predict how people with diabetic macular edema respond to anti-VEGF injections or a dexamethasone eye implant.

  Recruiting Vastra Gotaland Region · Mölndal and 1 other locations · NCT06984822

• Reactive Oxygen Species and Reproduction (ROAR)

  This study will see if oxidative stress levels in follicular fluid, blood, and sperm are linked to egg quality and IVF success for couples undergoing blastocyst culture with PGS.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06831019

• Using blueberries to improve health in women with prediabetes

  This study is testing if eating freeze-dried wild blueberry powder can help improve health, brain function, and gut health in women with prediabetes.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06735651

• Effects of wild blueberries on heart, brain, and gut health in adults with high blood pressure

  This study tests if eating freeze-dried wild blueberries can improve heart health, brain function, and gut health in adults aged 45-65 with high blood pressure.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06735599

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• How exposure to heavy metals, nanoparticles, and emerging contaminants relates to allergic skin and systemic metal reactions

  This project will test whether adults with allergic contact dermatitis or systemic metal allergies have different levels of heavy metals, nanoparticles, and related blood and urine markers compared with healthy adults.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Bologna and 1 other locations · NCT06529913

• Effects of royal jelly on inflammation in chronic kidney disease patients

  This study is testing if taking royal jelly can help reduce inflammation in people with chronic kidney disease who are on hemodialysis.

  Recruiting Universidade Federal Fluminense · Rio de Janeiro, Rio de Janeiro · NCT06438445

• Little cigar exposure and oxidative stress markers in adult smokers

  We will test whether using high- or low-oxidant little cigars changes markers of oxidative stress compared with your usual cigarette in adult daily cigarette smokers.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06310187

• Effects of Chardonnay marc on heart health

  This study is testing whether eating products made with Chardonnay marc can improve heart health and how our bodies respond after meals.

  Recruiting University of California, Davis · Davis, California · NCT05545865

• Exploring the role of LPC16:0 in fibromyalgia

  This study is trying to see how a specific compound called LPC16:0 affects people with fibromyalgia to help find better ways to diagnose and treat the condition.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT04832100

• How changes in brain blood flow affect breathing during sleep

  This project will test whether temporarily lowering blood flow to the brain changes how healthy adults' breathing responds to low oxygen and high carbon dioxide during normal sleep and short periods of low oxygen.

  Recruiting Phase 1/2 University of Calgary · Calgary, Alberta · NCT03255408

• Effects of chronic cannabis smoking on lung health

  This study is trying to see how long-term cannabis smoking affects lung health in regular users compared to non-smokers.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT02480283

• Evaluating oxidative stress and inflammation in Gaucher disease

  This study is testing how oxidative stress and inflammation affect adults with Gaucher disease type I by looking at blood samples taken over three months.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT02437396

NIH-funded research (newest 40 of 150)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How vitamin B12 helps the gum-disease bacterium survive

  Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.

  NIH research University of Louisville · Louisville, United States · NIH-11506468

• Pancreatic beta cells, oxidative stress, and gestational diabetes

  A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11449183

• Environmental air pollutants linked to preeclampsia risk in pregnancy

  This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11449018

• Oxidative stress and Nlrp3 inflammasome activation in eye lens aging

  This grant looks at how aging and oxidative stress drive inflammation in the eye lens, which could help prevent age-related eye diseases.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11448772

• Glyphosate exposure and young adults' metabolic health

  A study will look at how glyphosate exposure relates to metabolism and liver health in young adults, using urine measurements and health data.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11432034

• Protein translation control in heart failure under oxidative stress

  This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.

  NIH research University of Arizona · Tucson, United States · NIH-11404793

• Electronic cigarettes and breast cancer: how vaping-related stress may affect tumor growth

  A small study explores whether electronic cigarette use creates oxidative stress that could promote breast cancer growth, using a mouse model and human cancer cells.

  NIH research Charles R. Drew University of Med & Sci · Los Angeles, United States · NIH-11399733

• Oxidative stress, mitochondria, and heart failure in a mouse model and future neonatal heart failure studies

  A mentored clinician–scientist program will study how oxidative stress affects heart cell powerplants and heart function, using a special mouse model, with plans to apply findings to neonatal heart disease in the future.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11389401

• Role of oxidative stress in Fuchs endothelial corneal dystrophy

  A patient-friendly look at how oxidative stress may contribute to Fuchs endothelial corneal dystrophy and what this NIH grant aims to learn to improve eye health.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11380762

• Understanding why some patients have heart damage from doxorubicin and how to predict it

  This grant looks at why doxorubicin can damage the heart in some patients and how genetic differences, especially related to oxidative stress, might help predict who is at higher risk.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11379116

• LRRK2 and Oxidative Stress in Parkinson’s Disease

  A study from the University of Pittsburgh looks at how a human protein called LRRK2 interacts with oxidative stress to contribute to Parkinson’s disease, with findings aimed at understanding why some people develop the condition and how to target it.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11378506

• Oxidative stress and tiny blood vessels after gestational diabetes

  This study looks at why women who had gestational diabetes may have higher risk of heart and diabetes problems, by checking how oxidative stress affects tiny blood vessels.

  NIH research University of Iowa · Iowa City, United States · NIH-11377501

• Understanding glaucoma risk and mitochondria in eye cells

  A study to understand why people develop glaucoma by looking at how mitochondria and oxidative damage in eye drainage cells might contribute to high eye pressure.

  NIH research Washington University · Saint Louis, United States · NIH-11374549

• Molecular clues about how Salmonella handles oxidative stress

  This grant explores how Salmonella bacteria survive the body's attack during infection, which could lead to better treatments for dangerous non-typhoidal Salmonella illnesses.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11369883

• Targeting leukemia metabolism with metabolic imaging in AML

  Researchers are testing a new way to image and target the energy metabolism of acute myeloid leukemia to find vulnerabilities that could lead to better treatments.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11360586

• Lower Airway Microbes and Oxidative Stress in Inflammatory Lung Disease

  A study to understand how microbes in the lungs influence oxidative stress and inflammation in lung diseases, with a focus on how smoking-related damage and sulfur compounds affect patients.

  NIH research New York University School of Medicine · New York, United States · NIH-11356103

• Mitochondrial protection by PKD1 in Parkinson's disease

  This project looks at how a protein called PKD1 helps protect brain cells' mitochondria from oxidative damage in people with Parkinson's disease.

  NIH research University of Georgia · Athens, United States · NIH-11348908

• Understanding how oxygen stress affects bacteria and what keeps them alive

  This NIH grant supports research on how bacteria handle oxidative stress from oxygen and what protects their DNA and enzymes, which could lead to new ways to fight bacterial infections.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11333223

• Understanding how oxidative stress affects proteins and cells to improve treatments for radiation-related damage

  Scientists are studying how oxidative stress harms proteins in bacteria and human cells to pinpoint targets that could help diagnose and treat radiation-related damage and aging.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11331282

• Placental NHIP protein may protect developing neurons from oxygen stress in autism

  Researchers are studying a tiny, newly found brain-protective peptide called NHIP that may guard developing neurons from oxygen stress linked to autism.

  NIH research University of California at Davis · Davis, United States · NIH-11326195

• Investigating how oxidative stress affects heart function in heart failure.

  This study is looking at how oxidative stress affects heart health, especially in people with heart failure, and it aims to find new ways to help treat this condition, particularly for premature infants who are more vulnerable to heart issues.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11324071

• Fluorescent sensors to visualize oxidative stress in Alzheimer's

  They are creating tiny fluorescent sensors that light up where harmful oxidative stress happens in Alzheimer's models so researchers can see when and where damage occurs.

  NIH research University of Virginia · Charlottesville, United States · NIH-11321239

• Targeting how oxidative stress drives harmful cell death in TB infection

  This grant tests a new approach to reduce deadly cell death patterns in people with tuberculosis, especially those who might also have HIV, by focusing on how oxidative stress influences immune cells.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11319886

• Placenta-on-a-chip to study healthy and stressed pregnancies

  A placental–maternal interface chip is being developed to model normal pregnancies and those affected by oxidative stress and inflammation, to help find ways to reduce pregnancy complications.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11313830

• How fat cells drive artery inflammation in atherosclerosis

  This project looks at how signals from fat cells can trigger artery inflammation that leads to heart attacks and strokes.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11303332

• How mouth bacteria resist saliva's natural oxidants and affect tooth decay

  This work looks at how some common mouth bacteria protect themselves from a natural saliva chemical and how that may change the mix of bacteria linked to cavities.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11300219

• Oxidative stress in age-related osteoarthritis

  Looking at whether too much damaging oxygen activity in joint cells causes cartilage breakdown in older adults with osteoarthritis.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11299495

• Targeting stress defenses in eye melanoma that spreads to the liver

  Researchers are working to weaken tumor cells' defenses against oxidative damage so liver metastases from uveal (eye) melanoma in adults become more vulnerable to treatment.

  NIH research Drexel University · Philadelphia, United States · NIH-11298994

• How aging and cell stress damage salivary glands in Sjögren’s

  Researchers are testing whether getting older and increased oxidative (cell) stress make salivary glands more likely to be damaged in Sjögren’s, using mouse models that mimic the disease.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11296942

• How a mother's lifetime stress may shape a child’s asthma risk

  A mom’s long-term stress, including past traumas, could influence her baby’s growing lungs and later risk of asthma.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11296939

• How e-cigarette chemicals might cause lung cancer

  This research looks at whether chemicals from e-cigarettes cause harmful inflammation and DNA damage that could lead to lung cancer in people who vape.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11285142

• How heart attacks and oxidative stress damage the heart's calcium release channel

  Researchers will see if specific chemical bonds form between parts of the heart's calcium release channel during oxidative damage from a heart attack and cause calcium imbalance that leads to poor heart contractions and arrhythmias.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11264827

• Blood-vessel oxidative stress linked to brain and heart damage

  This research looks at whether extra oxidative stress in blood-vessel cells can cause nerve and heart damage that may relate to dementia.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11259432

• High Salt and Kidney Metabolism Fueling Hypertension

  High salt intake may change kidney metabolism and drive high blood pressure, especially in people of African American and Asian descent.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11252558

• Why female blood vessel muscle cells resist damage from oxidative stress

  Researchers are looking at whether female blood vessel muscle cells keep their mitochondria healthier during the burst of oxidative stress that happens when blood flow returns after an ischemic stroke, with the hope of improving blood flow recovery for stroke patients.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11249658

• How Candida albicans withstands the immune system's oxidative attack

  This project is learning whether a specific part of the Candida albicans Tor1 protein helps the fungus survive the immune system's oxidative defenses, with the goal of guiding new antifungal strategies for people with Candida infections.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11237093

• Gene switches that drive damaging immune-related brain inflammation in multiple sclerosis

  Researchers are mapping how gene switches in brain immune cells cause harmful oxidative stress to point toward new treatments for people with multiple sclerosis.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11235884

• How the receptor FSHR-1 helps nerves and muscles communicate during normal and stress conditions

  This project looks at whether a receptor called FSHR-1 helps protect nerve-to-muscle signaling from oxidative stress that can contribute to conditions like Alzheimer’s disease.

  NIH research Butler University · Indianapolis, United States · NIH-11221240

• Investigating how microRNA-210 affects oxidative stress in patients with peripheral artery disease

  This study is looking at how a tiny molecule called microRNA-210 affects muscle health in people with peripheral artery disease (PAD) and how it might help doctors create better, personalized treatments for patients after they have surgery to improve blood flow.

  NIH research University of West Florida · Pensacola, United States · NIH-11220628

• Using fluorescent indicators to measure oxidative stress in Alzheimer's disease

  This study is working on new tools to help scientists see how oxidative stress affects brain cells in mice with Alzheimer's disease, which could lead to better understanding and treatments for the condition.

  NIH research University of Virginia · Charlottesville, United States · NIH-11212190

Related topics

Quick answers

How many Oxidative Stress clinical trials are recruiting right now?

32, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (10 trials), Turkey (Türkiye) (4 trials), Spain (4 trials), Brazil (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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