Effects of wild blueberries on heart, brain, and gut health in adults with high blood pressure
Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure
This study tests if eating freeze-dried wild blueberries can improve heart health, brain function, and gut health in adults aged 45-65 with high blood pressure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 45 Years to 65 Years |
| Sex | All |
| Sponsor | Georgia State University Academic / other |
| Locations | 1 site (Atlanta, Georgia) |
| Trial ID | NCT06735599 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of freeze-dried wild blueberries on cardiovascular health, cognitive function, and gut microbiota in non-Hispanic Black and White adults aged 45-65 with elevated blood pressure. Participants will be randomly assigned to receive either wild blueberries or a placebo for a specified duration. The study will assess various health parameters, including blood pressure, memory, and gut health, to determine the potential benefits of blueberry consumption. This research addresses a significant gap in understanding the impact of dietary interventions on hypertension and related health outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 45-65 with a diagnosis of elevated blood pressure or stage 1 hypertension and a BMI between 25-30 kg/m2.
Not a fit: Patients with allergies to berries, those on multiple antihypertensive medications, or individuals with certain medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a natural dietary intervention to improve heart, brain, and gut health in individuals with high blood pressure.
How similar studies have performed: While studies have shown health benefits from blueberry consumption, this specific comprehensive approach comparing effects in different racial groups with high blood pressure is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals 45-65 years of age * Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and/or diastolic blood pressure = 80-89 mmHg) for at least 6 months * BMI 25-35 kg/m2 via anthropometric measurements. * Ability to give consent Exclusion Criteria: * Allergies to berries * Use of one hypertensive drug for less than three months * Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury * Smoking * Alcohol consumption (\>2 drinks/day) * Consuming antioxidant, probiotic, and prebiotic supplements * Pregnant or lactating * Participating in a weight loss program
Where this trial is running
Atlanta, Georgia
- Georgia State University — Atlanta, Georgia, United States (Recruiting)
Study contacts
- Principal investigator: Rafaela G Feresin, PhD — Georgia State University
- Study coordinator: Rafaela G Feresin, PhD
- Email: berries@gsu.edu
- Phone: 404-413-1233
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.