How a specific pathway affects blood pressure and artery health
Official title: Intersection of the PPARγ-RhoBTB1-Cullin-3 Pathway and Renin-Angiotensin System in Blood Pressure, Vascular Function and Arterial Stiffness
Funded at Medical College of Wisconsin · NIH-11034272 · Data updated 2026-11-12
This study is looking at how a certain cellular process affects blood pressure and the stiffness of blood vessels, with the goal of finding new ways to help people with high blood pressure feel better and improve their heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2032 |
| Funding year | 2025 |
| Award (this year) | $1,092,000 |
| NIH project number | 1R35HL177123-01 |
| Project ID | NIH-11034272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from hypertension or related cardiovascular conditions.
✕Less likely to help
Patients with normal blood pressure and no cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the relationship between a specific cellular pathway and its impact on blood pressure regulation and arterial stiffness. It focuses on how the PPARγ-RhoBTB1-Cullin-3 pathway influences the production of nitric oxide, a key molecule that helps blood vessels relax. By understanding this pathway, the research aims to identify potential treatments that could improve vascular function and reduce hypertension. Patients may benefit from insights into new therapeutic strategies that target this pathway to enhance their cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension and improved vascular health.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for improving vascular function and managing blood pressure.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Sigmund, Curt Daniel — Medical College of Wisconsin
- Study coordinator: Sigmund, Curt Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.