Using nicotinamide riboside to lower blood pressure and improve artery health in older adults
Official title: Nicotinamide riboside supplementation for treating elevated systolic blood pressure and arterial stiffness in middle-aged and older adults
Funded at University of Colorado · NIH-10539289 · Data updated 2026-11-12
This study is looking at whether taking nicotinamide riboside can help lower high blood pressure and improve blood vessel health in middle-aged and older adults, offering a friendly option for those who might find lifestyle changes challenging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | February 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $437,530 |
| NIH project number | 5R01AG061514-05 |
| Project ID | NIH-10539289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are middle-aged and older adults experiencing elevated systolic blood pressure.
✕Less likely to help
Patients under 21 years old or those with normal blood pressure levels may not benefit from this research.
What this research studies
This research investigates the effects of nicotinamide riboside supplementation on reducing elevated systolic blood pressure and improving arterial stiffness in middle-aged and older adults. The study aims to understand how this supplement can enhance the body's ability to produce NAD+, a molecule that plays a crucial role in cellular health and function. By focusing on older adults, the research seeks to provide a potential alternative to traditional lifestyle changes that may be difficult for this population to maintain. Participants will be monitored for changes in blood pressure and arterial health over the course of the study.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for managing high blood pressure and improving cardiovascular health in older adults.
How similar studies have gone: Previous research has shown promising results with NAD+ boosting strategies in animal models, indicating potential for success in human applications.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Seals, Douglas R — University of Colorado
- Study coordinator: Seals, Douglas R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.