Arterial health after pregnancy complications: uncovering heart disease risk in women
Official title: Arterial Stiffness and Wave Reflection: Physiological Contributors to CVD after Adverse Pregnancy Outcomes
Funded at University of Michigan at Ann Arbor · NIH-11423644 · Data updated 2026-11-12
This project looks at why some women who had complications during pregnancy are at higher risk for heart disease later and how to spot those at risk earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $392,397 |
| NIH project number | 5R01HL167841-04 |
| Project ID | NIH-11423644 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women with a history of adverse pregnancy outcomes who are premenopausal and able to participate in follow-up evaluations.
✕Less likely to help
If you do not have a history of adverse pregnancy outcomes, this study may not apply to you.
What this research studies
If you had a pregnancy complication like high blood pressure or growth issues, this study follows thousands of women to understand changes in blood vessel function that can predict future heart problems. The researchers will measure how the arteries respond to stress and track signs of stiffening or altered wave reflections over time. By identifying sensitive indicators beyond traditional risk factors, they hope to guide personalized prevention strategies. The study builds on existing data from a large, diverse cohort and will monitor participants through follow-up visits and biosample analyses.
Why it matters
Potential benefit: Learning who is at higher risk could lead to earlier prevention and personalized lifestyle or medical strategies to protect heart health.
How similar studies have gone: Previous smaller studies suggested vascular changes after APOs; this larger, diverse cohort aims to confirm and extend those findings.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Lane, Abbi Danielle — University of Michigan at Ann Arbor
- Study coordinator: Lane, Abbi Danielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.