Understanding how aging affects blood vessel stiffness and high blood pressure
Investigation into Arterial Stiffness and Hypertension
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10678777
This study is looking at how aging affects blood vessel stiffness and high blood pressure, focusing on a gene called KDM6A that might help keep your blood vessels flexible, with the goal of finding ways to improve heart health for older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10678777 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between arterial stiffness and hypertension, particularly as it relates to aging. The study focuses on a specific gene, KDM6A, which may play a crucial role in how blood vessels maintain their elasticity. By examining vascular smooth muscle cells, the researchers aim to uncover the molecular mechanisms that contribute to increased arterial stiffness and hypertension in older adults. The research employs advanced methodologies to explore these connections and seeks to identify potential interventions for improving vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing hypertension or related cardiovascular issues.
Not a fit: Patients who are young and do not have hypertension or arterial stiffness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for reducing arterial stiffness and managing hypertension in aging populations.
How similar studies have performed: Other research has shown promising results in understanding arterial stiffness and its implications for cardiovascular health, making this approach both relevant and potentially impactful.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, ZHONGJIE — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: SUN, ZHONGJIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: hypertensive disease, hypertensive disorder