Predicting preeclampsia early using arterial stiffness in high-risk pregnancies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to improve early detection of preeclampsia (PE) in high-risk pregnancies by utilizing a non-invasive test to measure arterial stiffness, alongside blood biomarkers and ultrasound imaging. The study will recruit 2400 participants across multiple sites in Canada, the US, and the UK, conducting assessments in both the first and second trimesters of pregnancy. By identifying early signs of PE, the study seeks to develop strategies for better management and prevention of this serious condition. The findings could lead to significant advancements in maternal health care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Singleton pregnancy
* Presence of at least 1 high-risk factor or 2 moderate-risk factors for pre-eclampsia

Exclusion Criteria:

* \>14 weeks gestation
* Multiple pregnancy
* History of heart disease, stroke, or peripheral arterial disease
* Infectious diseases/conditions, such as Hepatitis B/C, HIV, and COVID19

Where it's running

• Royal Victoria Hospital
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Stella S Daskalopoulou, MD, PhD — Research Institute of the McGill University Health Centre
• Study coordinator: Helena Papacostas, PhD
• Email: helena.papacostas@rimuhc.ca
• Phone: 514 934-1934

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.