Condition

Aortic Valve Disease clinical trials and research

• 21Clinical trials
• 16NIH research projects
• 17Countries

Newest Aortic Valve Disease clinical trials

All recruiting trials (21)

• KONECT RESILIA Aortic Valved Conduit real-world use in adults needing valve and ascending aorta replacement

  This study tests how the KONECT RESILIA aortic valved conduit performs in adults needing aortic valve and ascending aorta replacement.

  Recruiting at 3 sites Edwards Lifesciences · München, Bavaria and 2 other locations · NCT07619872

• Savvywire versus standard LV guidewires during transfemoral TAVI

  For people 50 and older having transfemoral TAVI, researchers will compare the Savvywire and standard LV guidewires to see if the Savvywire improves pacing and procedure-related blood flow.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07366671

• EmStop Embolic Protection System for TAVR in Aortic Valve Stenosis

  This study tests whether the EmStop protective device can safely capture and remove debris during transcatheter aortic valve replacement in adults with severe aortic valve stenosis.

  Recruiting at 7 sites EmStop Inc · Thousand Oaks, California and 6 other locations · NCT07276711

• Tracking progression and consequences of heart valve disease

  This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.

  Recruiting at 15 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Fuzhou, Fujian and 14 other locations · NCT07267117

• Real-world outcomes of the INSPIRIS RESILIA aortic valve in adults

  This registry will collect real-world data to see how the INSPIRIS RESILIA aortic valve performs in adults undergoing aortic valve replacement.

  Recruiting at 15 sites Edwards Lifesciences · Heidelberg, Baden-Wurttemberg and 14 other locations · NCT07120048

• Transcatheter JenaValve or J-Valve treatment for severe aortic regurgitation

  This project will try two transcatheter heart valves (JenaValve and J-Valve) to treat people with severe symptomatic aortic regurgitation who are high risk for open-heart surgery.

  Recruiting Prince of Wales Hospital, Shatin, Hong Kong · Hong Kong, Shatin · NCT07021612

• CardioHeartConnect: Home Peloton cardiac rehab after TAVR

  This trial tests whether an eight-week home-based Peloton program paired with a smartwatch helps people recovering from TAVR become more active and improve heart-related health compared with educational materials.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07008911

• Contactless vibrometer pulse‑wave test for heart and artery health

  This pilot will try a contactless laser‑Doppler vibrometry and microwave radar device (Cardio P4) in people aged 58–72 to see if it can detect arterial stiffness and signs of coronary artery disease, aortic stenosis, or heart failure.

  Recruiting HJN Sverige AB/Neko Health · Stockholm · NCT07001007

• Observing the progression of moderate aortic valve disease

  This study looks at how moderate aortic valve disease gets worse over time to help doctors understand what affects its progression and how treatments might help patients.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06595992

• Long-term outcomes of the Ross procedure for aortic valve replacement

  This study looks at how well the Ross procedure, which uses a person's own valve to replace a damaged aortic valve, works over the long term for patients needing heart surgery.

  Recruiting Baylor Research Institute · Plano, Texas · NCT06352671

• Exploring kinocardiography for diagnosing aortic valve disease and aneurysms

  This study is testing if kinocardiography can help doctors better diagnose aortic valve disease and aortic aneurysms in patients.

  Recruiting Université Libre de Bruxelles · Brussels · NCT06286358

• Investigating multiple and mixed heart valve diseases

  This study looks at how common different types of heart valve diseases are and their features by gathering information from patients around the world who have been diagnosed with these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06235385

• Using rapid atrial pacing to predict the need for pacemaker implantation after TAVI

  This study is testing if a quick heart pacing method can help doctors predict which patients will need a permanent pacemaker after getting a new heart valve.

  Recruiting at 2 sites National and Kapodistrian University of Athens · Brussels and 1 other locations · NCT06189976

• Assessing Lipoprotein(a) and Fibrinolysis in Heart Disease

  This study is testing whether lowering a specific cholesterol called Lipoprotein(a) with certain medications can help improve the body's ability to dissolve blood clots in people with heart disease.

  Recruiting East and North Hertfordshire NHS Trust · Stevenage · NCT06126367

• Assessing risk factors and prognosis for aortic valve diseases

  This study is trying to find out what factors affect the health of people with aortic valve disease while they're in the hospital, to help doctors make better decisions about their care.

  Recruiting at 7 sites Sun Yat-sen University · Guangzhou, Guangdong and 6 other locations · NCT06069232

• Using UniLine Bioprosthesis for Aortic and Mitral Valve Diseases

  This study is testing how well the UniLine bioprosthesis works for people with aortic and mitral valve diseases over the long term, including any problems that might come up after the replacement.

  Recruiting Closed Joint-Stock Company NeoCor · Kemerovo, Kemerovo Oblast · NCT06025149

• Investigating Dexamethasone and Olanzapine in Heart Surgery

  This study is testing different treatments and strategies during heart surgery to see if they can help patients recover faster and spend more days at home after the operation.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05635227

• Transcatheter aortic valve replacement for severe aortic valve disease

  This study is trying to see how well transcatheter aortic valve replacement works for people with severe aortic valve problems, especially younger patients, and what complications might occur.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT05439863

• Transcatheter valve implantation for severe aortic regurgitation

  This study is testing if a new heart valve procedure called TAVR can help people with severe aortic regurgitation who can't have traditional surgery due to their health risks.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT04864145

• Evaluation of a new valved graft for heart surgery

  This study is testing a new heart valve graft in patients having heart surgery to see how well it works and if it's safe.

  Recruiting at 21 sites Abbott Medical Devices · Birmingham, Alabama and 24 other locations · NCT04754217

• Monitoring heart rhythms in patients with new left bundle branch block after heart valve surgery

  This study is testing how often heart rhythm problems happen in patients who develop a new heart condition after valve surgery and will use a special device to monitor their heartbeats during recovery.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT02153307

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• GATA4's role in why some hearts are born with two valve cusps

  A study in mice and human genetics will look at how a specific GATA4 gene change leads to bicuspid aortic valve and related heart problems.

  NIH research University of Arizona · Tucson, United States · NIH-11450686

• AI-guided prediction of aortic valve disease progression using CT scans

  A patient-friendly AI tool analyzes CT angiography data to predict how quickly aortic valve disease may advance and the risk of complications after valve replacement.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11379955

• Small molecule therapy for calcific aortic valve disease

  A new drug candidate is being studied to slow or stop calcification of the aortic valve in adults with valve disease.

  NIH research J. David Gladstone Institutes · San Francisco, United States · NIH-11325033

• Understanding and treating congenital aortic valve problems

  This project develops medicines targeting the genetic and molecular causes of malformed aortic valves to help people born with bicuspid or other congenital valve problems avoid or delay surgery.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11310034

• Understanding why some people with calcific aortic valve disease develop atherogenic vs non-atherogenic patterns

  This NIH-funded project explores why some people with aortic valve disease have accompanying atherosclerosis while others do not, using human genetics, proteomics, and imaging data to uncover differences that could lead to better treatments.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11281583

• Lab-grown models of how aging and sex affect aortic valve narrowing

  Researchers will build lab-grown heart valve models that mimic aging and male/female differences to learn why older adults develop aortic valve narrowing.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11249117

• Cadherin-11's role in aortic valve calcification

  This project looks at whether blocking a protein called cadherin-11 can stop or even reverse calcium buildup in the aortic valve of older adults with aortic stenosis.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11239089

• Investigating the role of cadherin-11 in heart valve disease in older adults

  This study is looking at how a protein called cadherin-11 affects calcific aortic valve disease in people over 65, to see if targeting it can help slow down or even reverse the disease, and to find out if it can help doctors decide when to treat patients with aortic stenosis.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11231564

• Using AI to understand aortic valve disease and predict patient outcomes

  This project uses artificial intelligence to better understand aortic valve disease from CT scans and predict how the condition might progress for patients.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11181172

• Understanding and treating congenital aortic valve disease

  This study is looking into congenital aortic valve disease to understand what causes it and to find new treatments that might help people avoid surgery, especially by exploring genetic factors and potential medications.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11133027

• New treatment for calcific aortic valve disease

  This study is looking for a new medicine to help people with calcific aortic valve disease, a heart problem that gets more common as we age, by using special cells from patients to find ways to stop heart valve cells from turning into bone-like cells, which causes the disease.

  NIH research J. David Gladstone Institutes · San Francisco, United States · NIH-11085293

• Understanding how mechanical stress leads to early calcification in bicuspid aortic valves

  This study is looking into why people with a bicuspid aortic valve, which is a heart condition where the valve has only two flaps instead of three, often develop calcium buildup, and it aims to find better ways to treat this issue.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11066100

• Investigating the role of cadherin-11 in heart valve disease in older adults

  This study is looking at how a protein called cadherin-11 affects calcific aortic valve disease in people over 65, to see if targeting it can help slow down or even reverse the disease, and to find out if it can help doctors decide when to treat patients with aortic stenosis.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11036372

• Understanding how aging affects aortic valve disease

  This study is looking into how age and gender affect aortic valve disease, which is common in older adults, by creating models to see how heart valves change as we get older, so we can better understand why aging is a big risk factor and how it impacts men and women differently.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11003747

• Using a natural compound to treat calcific aortic valve disease

  This study is looking at a new treatment for calcific aortic valve disease, a heart condition that many older adults face, by using a natural compound called emodin to see if it can help stop or even reverse the disease.

  NIH research Acepre, LLC · Columbia, United States · NIH-10822082

• How aortic valve function and heart devices affect blood transport in older adults with valve disease

  This study is looking at how the movement of the aortic valve and the use of heart pumps (LVADs) affect the way bad cholesterol (LDL) moves around the heart, which is important for understanding and treating calcific aortic valve disease.

  NIH research University of North Texas · Denton, United States · NIH-10292320

Related topics

Quick answers

How many Aortic Valve Disease clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in China (5 trials), United States (4 trials), Germany (3 trials), France (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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