Examining blood pressure patterns in people at risk for heart disease
Official title: Diurnal Blood Pressure and Arterial Stiffness Patterns in Those at Increased Risk of Cardiovascular Disease
Run by University of Edinburgh · NCT04522765 · Data updated 2026-11-12
This study looks at daily blood pressure patterns in people at risk for heart disease, especially those with kidney issues, to see how these patterns might help identify who could benefit from specific treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | University of Edinburgh Academic / other |
| Locations | 1 site (Edinburgh) |
| Status | Recruiting |
| Started | March 17, 2020 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT04522765 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients attending NHS Lothian services who are classified as at increased risk of CVD, including those with chronic kidney disease and other related conditions.
✕Probably not a fit
Patients under 18 or over 90 years old, or those unable to provide informed consent, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to characterize diurnal blood pressure patterns in patients at increased risk of cardiovascular disease (CVD), particularly focusing on those with chronic kidney disease and other related conditions. It will assess 24-hour blood pressure and arterial stiffness to understand the implications of nocturnal blood pressure dipping and its association with CVD risk. The study also seeks to identify distinct patient groups who may benefit from targeted therapies based on their blood pressure patterns.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients at risk of cardiovascular disease, potentially reducing their risk of adverse events.
How similar studies have gone: While the approach of assessing diurnal blood pressure patterns is established, the specific focus on this patient cohort and the implications for chronic kidney disease is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients will be eligible to take part in the study if they attend NHS Lothian inpatient or outpatient services and can be classified as being at increased risk of CVD. This will include, but is not limited to, the following subgroups: 1. CKD as defined by the Kidney Disease Outcome Quality Initiative (K/DOQI) classification 2. AKI as defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification 3. Small vessel vasculitis 4. Kidney transplant recipient 5. Kidney donor We will also recruit a healthy control group from the community. Exclusion Criteria: 1. Age \<18 years and \>90 years 2. Lack of ability to provide informed consent
Where it's running
-
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom Recruiting
Study contacts
- Principal investigator: Neeraj Dhaun, MBChB PhD — University of Edinburgh
- Study coordinator: Neeraj Dhaun, MBChB PhD
- Email: bean.dhaun@ed.ac.uk
- Phone: 07968810899
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.