Right ventricular–arterial coupling during fluid loading in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study in ICU patients investigates right ventriculo-arterial coupling during fluid loading for acute circulatory failure. Echocardiography is used before and after fluid administration to measure coupling, primarily via the TAPSE/TRV ratio, and to compare other RV function indices. Secondary analyses will examine fluid responsiveness and venous congestion using VExUS and portal vein pulsatility. The aim is to understand how venous congestion and RV function interact to influence hemodynamic management in shock. Patients are included when fluid loading is clinically indicated and guided by standard ICU practice.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Critically ill hospitalized patients
* Age ≥ 18 years
* Patients undergoing fluid loading at the discretion of the attending physician, following prediction of fluid responsiveness using any recommended maneuver or dynamic parameter, in the setting of acute circulatory failure requiring vasopressor support and/or mean arterial pressure \< 65 mmHg (or a decrease of ≥ 30 mmHg from baseline in patients with chronic hypertension), and/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia)
* Affiliated with a national health insurance system

Exclusion criteria :

* Formal refusal from the patient or legally representative after information
* Patients transferred from another intensive care unit
* Pregnant or postpartum patients
* Acute respiratory distress (defined as respiratory rate ≥ 35 breaths/min and/or signs of increased work of breathing)
* Ongoing acute coronary syndrome
* Acute or pulmonale (defined by right ventricular dilation associated with paradoxical septal motion related to an abrupt increase in right ventricular afterload)
* Primary pulmonary arterial hypertension
* Intra-abdominal hypertension (intravesical pressure \> 15 mmHg)
* Poor echogenicity precluding adequate echocardiographic assessment of the right ventricle
* Severe valvular heart disease or early postoperative period following valvular surgery

Where it's running

• Marie Muller
  Reims, France Recruiting

Study contacts

• Study coordinator: Morgan CAPLAN
• Email: mcaplan@chu-reims.fr
• Phone: 03 10 73 60 22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.