Using Angiotensin II to Treat Vasoplegic Shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of angiotensin II infusion in patients experiencing distributive shock who have not achieved adequate blood pressure despite receiving other vasopressors. Patients aged 18 and older with a specific type of shock will receive an angiotensin II infusion, and blood samples will be collected before and after treatment to measure renin levels. The primary focus is on the number of days free from organ failure and ICU stay, while secondary outcomes include the need for additional vasopressors and other interventions. The study aims to better understand the role of renin in shock severity and the effectiveness of angiotensin II in managing blood pressure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with distributive shock lasting \< 72 hours
* a goal mean arterial pressure (65-85 mmHg) not achieved despite optimal fluid resuscitation (30 ml/kg cristalloid) and an infusion of at least noradrenaline 0.3 mcg/kg/min and vasopressin 0.03 IE/min
* the patient did not get angiotensin II before
* predicted survival is \>24h
* no limitations for active treatment

Exclusion Criteria:

* burns \>20% body area
* acute coronary syndrome
* bronchospasm
* liver disease (MELD ≥30)
* severe acute bleeding (need for 4 or more units of concentrated erythrocyte)
* acute mesenteric ischemia
* aortic dissection
* leucopenia \<1000/mm3
* pregnancy
* Raynaud disease, systemic sclerosis, vasospastic disease
* active venous or arterial thromboembolic disease
* the need for daily dose of hydrocortisone 500 mg or more
* ECMO
* cardiac index \<l/min/m2 (defined by echocardiography or invasive methods)
* central venous oxygen saturation (SCVO2) \>70%

Where it's running

• Medical ICU, University Medical Centre Maribor
  Maribor, Slovenia Recruiting
• Surgical ICU, University Medical Centre Maribor
  Maribor, Slovenia Recruiting

Study contacts

• Study coordinator: Andreja Möller Petrun, PhD
• Email: drejapet@web.de
• Phone: +38623211571

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.