Understanding how aging cells affect patients with circulatory shock
Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States
This study looks at how aging cells in the blood might affect patients who have gone through circulatory shock, to see if they contribute to complications like infections and heart problems after recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 520 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT03559569 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of endothelial and leukocyte senescence in patients experiencing circulatory shock, a critical condition characterized by acute organ dysfunction. The researchers aim to determine how premature aging of these cells contributes to the development of secondary infections and cardiovascular diseases in survivors of circulatory shock. By analyzing biological samples, the study seeks to enhance understanding of the underlying mechanisms that lead to these complications, potentially informing new management strategies for affected patients.
Who should consider this trial
Good fit: Ideal candidates for this study are patients experiencing circulatory shock who have health care insurance.
Not a fit: Patients who refuse to participate in clinical research, pregnant or breastfeeding women, and those under a protective order may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and management strategies for cardiovascular diseases and infections in patients recovering from circulatory shock.
How similar studies have performed: While the specific approach of this study may be novel, related research has indicated that understanding cellular senescence can provide insights into complications following critical illnesses.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Circulatory shock * patient with health care insurance Exclusion criteria: * Patients' refusal to participate in clinical research * Pregnant woman * Breastfeeding woman * A patient with a protective order
Where this trial is running
Strasbourg
- Hôpitaux Universitaires de Strasbourg - Service de Réanimation médicale du NHC — Strasbourg, France (Recruiting)
Study contacts
- Principal investigator: Ferhat MEZIANI — Hôpitaux Universitaires de Strasbourg
- Study coordinator: Morgane CLERC
- Email: morgane.clerc@chru-strasbourg.fr
- Phone: 03 88 11 68 55
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.