Understanding how aging cells affect patients with circulatory shock
Official title: Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States
Run by University Hospital, Strasbourg, France · NCT03559569 · Data updated 2026-11-12
This study looks at how aging cells in the blood might affect patients who have gone through circulatory shock, to see if they contribute to complications like infections and heart problems after recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 520 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | January 7, 2019 |
| Main results expected | February 2028 |
| Study ends | March 2028 |
| Registry record updated | March 10, 2025 |
| Trial ID | NCT03559569 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients experiencing circulatory shock who have health care insurance.
✕Probably not a fit
Patients who refuse to participate in clinical research, pregnant or breastfeeding women, and those under a protective order may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the role of endothelial and leukocyte senescence in patients experiencing circulatory shock, a critical condition characterized by acute organ dysfunction. The researchers aim to determine how premature aging of these cells contributes to the development of secondary infections and cardiovascular diseases in survivors of circulatory shock. By analyzing biological samples, the study seeks to enhance understanding of the underlying mechanisms that lead to these complications, potentially informing new management strategies for affected patients.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and management strategies for cardiovascular diseases and infections in patients recovering from circulatory shock.
How similar studies have gone: While the specific approach of this study may be novel, related research has indicated that understanding cellular senescence can provide insights into complications following critical illnesses.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Circulatory shock * patient with health care insurance Exclusion criteria: * Patients' refusal to participate in clinical research * Pregnant woman * Breastfeeding woman * A patient with a protective order
Where it's running
-
Hôpitaux Universitaires de Strasbourg - Service de Réanimation médicale du NHC
Strasbourg, France Recruiting
Study contacts
- Principal investigator: Ferhat MEZIANI — Hôpitaux Universitaires de Strasbourg
- Study coordinator: Morgane CLERC
- Email: morgane.clerc@chru-strasbourg.fr
- Phone: 03 88 11 68 55
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.