Helping blood vessels work better after major bleeding and severe inflammation
Official title: Regulation of vascular function after traumatic-hemorrhagic shock and during inflammation
Funded at University of South Florida · NIH-11249160 · Data updated 2026-11-12
This research looks at how blood vessels behave after traumatic bleeding or severe inflammation to find ways to prevent dangerous low blood pressure in critically ill patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $375,000 |
| NIH project number | 5R35GM152056-03 |
| Project ID | NIH-11249160 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have had traumatic hemorrhage, septic or vasodilatory shock, or those willing to donate blood or tissue samples for research would be most relevant to this work.
✕Less likely to help
Patients with stable, well-controlled blood pressure or conditions unrelated to vascular shock are unlikely to receive direct benefit from this project.
What this research studies
You will be hearing about lab work that examines key receptors on blood vessels—like alpha1-adrenergic, vasopressin (AVPR1A), and angiotensin receptors—to see how they change after major bleeding or during strong inflammation. The team uses molecular experiments, tissue studies, and animal models to pinpoint the signals that make vessels lose their ability to tighten. They plan to compare normal and stressed vascular tissues and test approaches that might restore vessel function. The research is done at the University of South Florida and may also use human-derived samples when available.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that stabilize blood pressure and reduce deaths from vasodilatory shock in critically ill patients.
How similar studies have gone: Previous studies have shown that blood-vessel receptors fail during shock, but the detailed molecular mechanisms are not well understood, so this program uses newer molecular approaches and is relatively novel.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Majetschak, Matthias — University of South Florida
- Study coordinator: Majetschak, Matthias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.