Helping blood vessels work better after major bleeding and severe inflammation
Regulation of vascular function after traumatic-hemorrhagic shock and during inflammation
This research looks at how blood vessels behave after traumatic bleeding or severe inflammation to find ways to prevent dangerous low blood pressure in critically ill patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11249160 on NIH RePORTER |
What this research studies
You will be hearing about lab work that examines key receptors on blood vessels—like alpha1-adrenergic, vasopressin (AVPR1A), and angiotensin receptors—to see how they change after major bleeding or during strong inflammation. The team uses molecular experiments, tissue studies, and animal models to pinpoint the signals that make vessels lose their ability to tighten. They plan to compare normal and stressed vascular tissues and test approaches that might restore vessel function. The research is done at the University of South Florida and may also use human-derived samples when available.
Who could benefit from this research
Good fit: People who have had traumatic hemorrhage, septic or vasodilatory shock, or those willing to donate blood or tissue samples for research would be most relevant to this work.
Not a fit: Patients with stable, well-controlled blood pressure or conditions unrelated to vascular shock are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that stabilize blood pressure and reduce deaths from vasodilatory shock in critically ill patients.
How similar studies have performed: Previous studies have shown that blood-vessel receptors fail during shock, but the detailed molecular mechanisms are not well understood, so this program uses newer molecular approaches and is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Majetschak, Matthias — University of South Florida
- Study coordinator: Majetschak, Matthias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.