How blood vessel cells control inflammation after trauma and shock
Official title: Endothelial regulation of inflammation in trauma and hemorrhagic shock
Funded at University of Colorado Denver · NIH-11132696 · Data updated 2026-11-12
This study is looking at how the cells in your blood vessels help control inflammation after serious injuries and blood loss, with the goal of finding new ways to reduce harmful inflammation and protect your organs if you ever face such a situation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM146859-05 |
| Project ID | NIH-11132696 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe trauma or hemorrhagic shock.
✕Less likely to help
Patients with minor injuries or those not experiencing significant inflammation following trauma may not benefit from this research.
What this research studies
This research investigates how the cells lining blood vessels, known as endothelial cells, manage inflammation that can occur after severe trauma and hemorrhagic shock. The study focuses on a specific system involving antithrombin and heparan sulfate, which plays a role in signaling and regulating the immune response. By understanding how these systems work and how they can become dysregulated, the research aims to develop new clinical tools to reduce harmful inflammation and prevent organ failure in trauma patients. The research will explore the mechanisms behind the degradation and production of heparan sulfate and the therapeutic potential of specific antithrombin variants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce inflammation and improve recovery outcomes for trauma patients.
How similar studies have gone: Previous research has shown promise in understanding endothelial regulation of inflammation, suggesting that this approach could lead to meaningful advancements in treatment.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Cardenas, Jessica — University of Colorado Denver
- Study coordinator: Cardenas, Jessica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.