Endothelial control of inflammation after trauma and blood loss
Official title: Endothelial regulation of inflammation in trauma and hemorrhagic shock
Funded at University of Colorado Denver · NIH-11334325 · Data updated 2026-11-12
A doctor-scientist at a major hospital is studying how the blood vessel lining controls inflammation after serious injury and血 loss, with the goal of finding new ways to prevent organ failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM146859-06 |
| Project ID | NIH-11334325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have suffered severe trauma with risk of organ failure may be eligible for future trials or related studies.
✕Less likely to help
Patients without trauma-related inflammatory risk or those not meeting future trial criteria may not benefit directly.
What this research studies
This project investigates how the vascular endothelium modulates the body’s inflammatory response after severe trauma and hemorrhagic shock. It focuses on the antithrombin-heparan sulfate system and how endothelial receptors with a specific modification (3-OS sulfation) influence anti-inflammatory signals. The work includes translating lab findings toward potential clinical tools to reduce excessive inflammation and organ damage. Over the next five years, the team plans to map how 3-OS HSPG is degraded or made and to explore AT variants that could dampen inflammation. The research is designed to move from basic mechanisms toward potential therapies that could benefit trauma patients at risk for organ failure.
Why it matters
Potential benefit: If successful, the work could lead to new treatments that lessen inflammation and prevent organ injury after trauma and blood loss.
How similar studies have gone: Prior work has shown that targeting endothelial inflammation can impact organ injury, but the specific ATHSPG pathway is an emerging area with promising potential.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Cardenas, Jessica — University of Colorado Denver
- Study coordinator: Cardenas, Jessica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.