Multi-scale model to improve REBOA use in hemorrhagic shock
Official title: Development of a multi-scale closed loop model for hemorrhagic shock: a platform to assess REBOA performance
Funded at Texas Engineering Experiment Station · NIH-11403777 · Data updated 2026-11-12
A researcher team is building a computer model to better predict how to use REBOA, a device that can control bleeding in the torso, so patients with severe trauma may survive.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Engineering Experiment Station NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | June 10, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $512,726 |
| NIH project number | 5R01HL162633-05 |
| Project ID | NIH-11403777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with traumatic hemorrhagic shock who could benefit from endovascular hemorrhage control techniques.
✕Less likely to help
Patients without torso or abdominal bleeding who do not require endovascular intervention.
What this research studies
This project will create a detailed computational model of the cardiovascular system to simulate hemorrhagic shock and REBOA deployment. The model combines 3D and simplified (0D) components to capture heart–blood vessel interactions and ischemia-reperfusion effects. Researchers aim to identify optimal balloon size, timing, and duration to improve outcomes. The goal is to speed up innovation by reducing reliance on costly animal studies while still predicting real-body responses.
Why it matters
Potential benefit: If successful, the model could guide safer, more effective use of REBOA to reduce deaths from traumatic bleeding.
How similar studies have gone: Early computational models have shown promise in predicting physiological responses, but this multi-scale approach is expanding beyond prior work.
Where this research is happening
-
Texas Engineering Experiment Station
College Station, United States Active
Researchers
- Principal investigator: Rahbar, Elaheh — Texas Engineering Experiment Station
- Study coordinator: Rahbar, Elaheh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.