Argos system to track cardiac output changes in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares the Argos monitor's multi-beat analysis to the transpulmonary thermodilution reference for tracking changes in cardiac output during fluid boluses or vasopressor adjustments in patients with acute circulatory failure. It sits in ICU settings where PiCCO2/CIpwa measurements are used, examining real-time CI changes and how well Argos aligns with the established method. The study leverages existing invasive monitoring to assess whether a less invasive or alternative waveform-based estimate can reliably detect hemodynamic shifts. Outcomes focus on agreement between Argos-derived CI and the TPTD-based CI changes during intervention. The trial is sponsored by Bicêtre Hospital and conducted at Bicêtre Hospital in Le Kremlin-Bicêtre.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years old
* Hospitalisation in intensive care
* Haemodynamic monitoring with transpulmonary thermodilution already in place
* Hemodynamic intervention deemed necessary by the clinician in charge of the patient

  * Administration of a fluid bolus
  * Change in norepinephrine dosage or performance of a vasopressor test

Exclusion Criteria:

* Pregnancy
* Other therapeutic modification during volume expansion or the vasopressor test
* Refusal to participate by relatives of the patient or the patient himself or herself
* Non availability of investigators

Where it's running

• Bicêtre Hospital
  Le Kremlin-Bicêtre, France Recruiting

Study contacts

• Study coordinator: Christopher Lai, MD, PhD
• Email: christopher.lai@aphp.fr
• Phone: 12633816521

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.